Evidence map›Paper›PMID 34200464›Full record

ArticleMolecules (Basel, Switzerland)2021

Investigation of Antifungal Mechanisms of Thymol in the Human Fungal Pathogen,

Kwang-Woo Jung, Moon-Soo Chung, Hyoung-Woo Bai, Byung-Yeoup Chung, Sungbeom Lee

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Multifunctional Activity ofPlants (Basel, Switzerland) · 2026
    Article
  4. A review of the current anti-New microbes and new infections · 2026
    Review
  5. Review
  6. Review
  7. Anticandidal activity ofFrontiers in pharmacology · 2025
    Article
  8. Overcoming antifungal resistance inFrontiers in cellular and infection microbiology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kwang-Woo JungRadiation Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.
Moon-Soo ChungRadiation Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.
Hyoung-Woo BaiRadiation Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.ORCID 0000-0002-1122-171X
Byung-Yeoup ChungRadiation Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.
Sungbeom LeeRadiation Research Division, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si 56212, Jeollabuk-do, Korea.
Korea Atomic Energy Research Institute · KR

Funding

Ministry of Science and Information and Communications Technologies (ICT) None
6 · The paper itself

Abstract

Due to lifespan extension and changes in global climate, the increase in mycoses caused by primary and opportunistic fungal pathogens is now a global concern. Despite increasing attention, limited options are available for the treatment of systematic and invasive mycoses, owing to the evolutionary similarity between humans and fungi. Although plants produce a diversity of chemicals to protect themselves from pathogens, the molecular targets and modes of action of these plant-derived chemicals have not been well characterized. Using a reverse genetics approach, the present study revealed that thymol, a monoterpene alcohol from

Indexed as

Antifungal AgentsCalcineurinCryptococcosisCryptococcus neoformansErgosterolFungal ProteinsHumansMitogen-Activated Protein KinasesMonoterpenesSignal TransductionThymolThymus PlantAntifungal AgentsCalcineurinErgosterolFungal ProteinsMitogen-Activated Protein KinasesMonoterpenesThymolantifungal activitycalcium homeostasisCryptococcus neoformansergosterolN-glycosylationthymol

Identifiers

PMID34200464
PMCPMC8201179
OpenAlexW3166485785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.