Evidence map›Paper›PMID 34200434›Full record

ReviewInternational journal of molecular sciences2021

Roles of Key Ion Channels and Transport Proteins in Age-Related Hearing Loss.

Parveen Bazard, Robert D Frisina, Alejandro A Acosta, Sneha Dasgupta, Mark A Bauer, Xiaoxia Zhu, Bo Ding

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Parveen BazardDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0001-8729-6112
Robert D FrisinaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-7423-6257
Alejandro A AcostaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Sneha DasguptaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Mark A BauerDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Xiaoxia ZhuDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
Bo DingDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA.
University of South Florida · US

Funding

Structure and Function Services CoreP01AG009524 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI FRISINA, ROBERT D · 1992 to 2021
$23.2M
NIH HHS P01 AG009524
6 · The paper itself

Abstract

The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not yet fully delineated. In the present article, we highlight ion channels and transport proteins, which are integral for the proper functioning of the auditory system, facilitating the diffusion of various ions across auditory structures for signal transduction and processing. Like most other physiological systems, hearing abilities decline with age, hence, it is imperative to fully understand inner ear aging changes, so ion channel functions should be further investigated in the aging cochlea. In this review article, we discuss key various ion channels in the auditory system and how their functions change with age. Understanding the roles of ion channels in auditory processing could enhance the development of potential biotherapies for age-related hearing loss.

Indexed as

AgingAnimalsCarrier ProteinsHumansIon ChannelsPresbycusisCarrier ProteinsIon Channelsage-related hearing lossagingauditorycochleadeafnesshearinginner earion channelspotassium channelspresbycusis

Identifiers

PMID34200434
PMCPMC8201059
OpenAlexW3167586816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.