Evidence map›Paper›PMID 34200350›Full record

ArticleMolecules (Basel, Switzerland)2021

Paclitaxel-Loaded Magnetic Nanoparticles Based on Biotinylated

Vlad Constantin Ursachi, Gianina Dodi, Alina Gabriela Rusu, Cosmin Teodor Mihai, Liliana Verestiuc, Vera Balan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vlad Constantin UrsachiFaculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.
Gianina DodiAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.ORCID 0000-0002-5551-6077
Alina Gabriela RusuNatural Polymers, Bioactive and Biocompatible Materials Laboratory, Petru Poni Institute of Macromolecular Chemistry, 700487 Iasi, Romania.ORCID 0000-0002-8913-7446
Cosmin Teodor MihaiAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.ORCID 0000-0002-0945-5437
Liliana VerestiucFaculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.ORCID 0000-0002-3098-8406
Vera BalanFaculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.ORCID 0000-0002-5255-7586
Grigore T. Popa University of Medicine and Pharmacy · ROInstitutul de Chimie Macromoleculară Petru Poni

Funding

Grigore T. Popa University of Medicine and Pharmacy of Iasi 27499/2018
6 · The paper itself

Abstract

A considerable interest in cancer research is represented by the development of magnetic nanoparticles based on biofunctionalized polymers for controlled-release systems of hydrophobic chemotherapeutic drugs targeted only to the tumor sites, without affecting normal cells. The objective of the paper is to present the synthesis and in vitro evaluation of the nanocomposites that include a magnetic core able to direct the systems to the target, a polymeric surface shell that provides stabilization and multi-functionality, a chemotherapeutic agent, Paclitaxel (PTX), and a biotin tumor recognition layer. To our best knowledge, there are no studies concerning development of magnetic nanoparticles obtained by partial oxidation, based on biotinylated

Indexed as

Antineoplastic Agents, PhytogenicBiotinCell Line, TumorChitosanColloidsDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsHumansHydrophobic and Hydrophilic InteractionsMagnetite NanoparticlesMCF-7 CellsPaclitaxelPolymersAntineoplastic Agents, PhytogenicBiotinChitosanColloidsDelayed-Action PreparationsDrug CarriersMagnetite NanoparticlesN-palmitoyl chitosanPaclitaxelPolymersbiotinchitosandrug deliverymagnetic nanoparticlespaclitaxelviability assay

Identifiers

PMID34200350
PMCPMC8201305
OpenAlexW3171639864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.