ArticleMedical sciences (Basel, Switzerland)2021
Misleading HbA1c Measurement in Diabetic Patients with Hemoglobin Variants.
Article in Medical sciences (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women.Medicina (Kaunas, Lithuania) · 2025Trial
- Comparative analysis of enzymatic assay for HbA1c measurement with high performance liquid chromatography.Scientific reports · 2026Article
- Challenges in Glycemic Monitoring: Undetectable HbA1c Level in an Asymptomatic Patient With Hemoglobin E and Beta-Thalassemia Minor: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Diagnostic utility of fasting versus non-fasting blood glucose: contextualising testing strategies-a narrative review.Diabetology & metabolic syndrome · 2026Review
- The limitations and fallacies of relying on glycosylated hemoglobin for diagnosing and monitoring diabetes in Indian populations.The Lancet regional health. Southeast Asia · 2026Review
- Glycemic assessment when hemoglobin A1c is unreliable: a clinical-laboratory framework for kidney disease, anemia, and hemoglobinopathies.Frontiers in endocrinology · 2026Review
- Early diabetes screening via red blood cell mechanics using microfluidic chip integration.Mechanobiology in medicine · 2025Article
- HbA1c levels in hemoglobin H disease.Biochemistry and biophysics reports · 2025Article
- An incidental finding of a hemoglobin E variant in a diabetic patient with an abnormal glycated hemoglobin level: a case report.Journal of medical case reports · 2024Article
- Management of diabetes mellitus patients with sickle cell anemia: Challenges and therapeutic approaches.Medicine · 2024Review
- Abnormally Low HbABritish journal of biomedical science · 2024Review
- [Effects of Hemoglobin Variants on Glycosylated Hemoglobin Testing].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesHemoglobin A1c (HbA1c) is widely used for the monitoring and management of diabetes mellitus. The aim of this study is to investigate the influence of hemoglobin (Hb) variants on the measurement of HbA1c. MATERIALS AND
methodsHbA1c levels of 845 blood samples obtained from diabetic patients with various hemoglobin types were measured using a turbidimetric inhibition immunoassay and capillary electrophoresis.
resultsOf 845 patients with diabetes, 65.7% (555/845) have the normal hemoglobin type (A
conclusionsWe have demonstrated the erroneous nature of HbA1c measurement in patients with hemoglobin variants, especially in those without HbA expression. Therefore, in the population with a high prevalence of hemoglobinopathies, hemoglobin typing should be considered as basic information prior to HbA1c measurement.
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Registered trials
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