Evidence map›Paper›PMID 34200112›Full record

ArticleBiomolecules2021

SARS-CoV-2 and Skin: The Pathologist's Point of View.

Gerardo Cazzato, Giulia Mazzia, Antonietta Cimmino, Anna Colagrande, Sara Sablone, Teresa Lettini, Roberta Rossi, Nadia Santarella, Rossella Elia, Eleonora Nacchiero and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Gerardo CazzatoDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0325-4316
Giulia MazziaDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Antonietta CimminoDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Anna ColagrandeDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Sara SabloneDepartment of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-2864-3521
Teresa LettiniDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0860-3044
Roberta RossiDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Nadia SantarellaDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Rossella EliaDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, Italy.
Eleonora NacchieroDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, Italy.
Michele MarucciaDepartment of Emergency and Organ Transplantation, Section of Plastic and Reconstructive Surgery, University of Bari, 70124 Bari, Italy.ORCID 0000-0002-2122-2732
Andrea MarzulloDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.
Eugenio MaioranoDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0472-5338
Giuseppe GiudiceDepartment of Interdisciplinary Medicine, Section of Legal Medicine, Policlinico di Bari Hospital, University of Bari, 70124 Bari, Italy.
Giuseppe IngravalloDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-4792-3545
Leonardo RestaDepartment of Emergency and Organ Transplantation (DETO), Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-4335-4776
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has dramatically changed our lives and habits. In just a few months, the most advanced and efficient health systems in the world have been overwhelmed by an infectious disease that has caused 3.26 million deaths and more than 156 million cases worldwide. Although the lung is the most frequently affected organ, the skin has also resulted in being a target body district, so much so as to suggest it may be a real "sentinel" of COVID-19 disease. Here we present 17 cases of skin manifestations studied and analyzed in recent months in our Department; immunohistochemical investigations were carried out on samples for the S1 spike-protein of SARS-CoV-2, as well as electron microscopy investigations showing evidence of virions within the constituent cells of the eccrine sweat glands and the endothelium of small blood vessels. Finally, we conduct a brief review of the COVID-related skin manifestations, confirmed by immunohistochemistry and/or electron microscopy, described in the literature.

Indexed as

AdolescentAdultChildCOVID-19ErythemaFemaleHumansMaleMiddle AgedSARS-CoV-2SkinSkin DiseasesYoung AdultCOVID-19eruptionSARS-CoV-2skin

Identifiers

PMID34200112
PMCPMC8227624
OpenAlexW3170061884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.