Evidence map›Paper›PMID 34200107›Full record

Observational studyNutrients2021

Evaluation of Vitamin D (25OHD), Bone Alkaline Phosphatase (BALP), Serum Calcium, Serum Phosphorus, Ionized Calcium in Patients with Mandibular Third Molar Impaction. An Observational Study.

Vito Crincoli, Angela Pia Cazzolla, Mariasevera Di Comite, Lorenzo Lo Muzio, Domenico Ciavarella, Mario Dioguardi, Maria Eleonora Bizzoca, Giuseppe Palmieri, Antonietta Fontana, Arcangela Giustino and 4 more

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562426 (Relationship Between Maternal Awareness About Vitamin D for Under- Five Years Children and Their Health Status Outcomes), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06562426 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Relationship Between Maternal Awareness About Vitamin D for Under- Five Years Children and Their Health Status Outcomes: Cross Sectional Study

Typeobservational_patient_registrySponsorAlexandria UniversityRan2024 to 2025Enrolled300ConditionsMaternal Care Patterns, Child Nutrition Disorders, Vitamin D DeficiencyArmsDescriptive group on vitamin D awareness
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Nutrient intake and oral health outcomes in children with cow's milk allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Vito CrincoliDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, 70121 Bari, Italy.
Angela Pia CazzollaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.
Mariasevera Di ComiteDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, 70121 Bari, Italy.ORCID 0000-0003-2450-4425
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.ORCID 0000-0003-4633-4893
Domenico CiavarellaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.
Mario DioguardiDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.ORCID 0000-0003-0949-3457
Maria Eleonora BizzocaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.ORCID 0000-0002-6722-6499
Giuseppe PalmieriIndependent Researcher, 70100 Bari, Italy.
Antonietta FontanaClinical Pathology Unit, Polyclinic of Bari, 70124 Bari, Italy.
Arcangela GiustinoDepartment of Biomedical Sciences and Human Oncology, "Aldo Moro" University of Bari, 70121 Bari, Italy.
Michele Di CosolaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, 71122 Foggia, Italy.
Brescia VincenzoClinical Pathology Unit, Polyclinic of Bari, 70124 Bari, Italy.
Roberto LoveroClinical Pathology Unit, Polyclinic of Bari, 70124 Bari, Italy.
Francesca Di SerioClinical Pathology Unit, Polyclinic of Bari, 70124 Bari, Italy.
University of Foggia · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the levels of vitamin D (25OHD) and other bone biomarkers in patients with third molar impaction (TMI). Thirty males and 30 females with unilateral or bilateral impacted mandibular third molar, and 15 males and 15 females as a control group (CG) were recruited. Rx-OPT was used to evaluate dental position and Pederson index to measure the difficulty of the intervention. Bone biomarkers were measured through blood venous sample in TMI group and CG. Mann-Whitney test, Pearson's correlation coefficient, linear regression model were used to compare the different parameters in the two groups. 25OHD showed lower values in TMI group than in CG (

Indexed as

Molar, ThirdAdolescentAdultAlkaline PhosphataseBiomarkersCalciumCase-Control StudiesFemaleHumansLinear ModelsMaleMiddle AgedPhosphorusTooth, ImpactedVitamin DVitamin D DeficiencyAlkaline PhosphataseALPL protein, humanBiomarkersCalciumPhosphorusVitamin Dalkaline phosphataseALPL proteinhumanimpactedmandible/growth and developmentmolarthirdtoothtooth eruptionvitamin Dvitamin D deficiency

Identifiers

PMID34200107
PMCPMC8228145
OpenAlexW3166503979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.