ArticleBrain sciences2021
Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of transcranial direct current stimulation over dorsolateral prefrontal cortex in patients with prolonged disorders of consciousness: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Effect and mechanism of repetitive transcranial magnetic stimulation of angular gyrus on patients with consciousness disorder.Frontiers in neurologyTrial
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- The role of coupling among brain regions between the default mode network and the "Mesocircuit" Model in arousal in disorders of consciousness.Frontiers in neurology · 2026Article
- Individual trajectories for recovery of neocortical activity in disorders of consciousness.PLoS computational biology · 2025Article
- Electroencephalographic characteristics of transcutaneous auricular vagus nerve stimulation for prolonged disorders of consciousness: a study protocol.Frontiers in neuroscience · 2025Article
- Motor imagery-based brain-computer interface for differential diagnosis in prolonged disorders of consciousness.Frontiers in human neuroscience · 2025Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging.Frontiers in neuroscience · 2024Article
- The integrity of thalamo-dorsolateral prefrontal cortex tract: a key factor in residual consciousness in disorders of consciousness patients.Frontiers in neurology · 2024Article
- Article
- Behavioral scales variability in patients with prolonged disorders of consciousness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Functional networks in prolonged disorders of consciousness.Frontiers in neuroscience · 2023Review
- Clinical Decision on Disorders of Consciousness After Acquired Brain Injury: Stepping Forward.Neuroscience bulletin · 2023Review
- Electrophysiological correlates of thalamocortical function in acute severe traumatic brain injury.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Conventional and Investigational Approaches Leveraging Clinical EEG for Prognosis in Acute Disorders of Consciousness.Seminars in neurology · 2022Review
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Authors and funding
5 authors.
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Abstract
Recent research indicates prolonged disorders of consciousness (PDOC) result from structural and functional impairments to key cortical and subcortical networks, including the default mode network (DMN) and the anterior forebrain mesocircuit (AFM). However, the specific mechanisms which underpin such impairments remain unknown. It is known that disruptions in the striatal-pallidal pathway can result in the over inhibition of the thalamus and lack of excitation to the cortex that characterizes PDOC. Here, we used spectral dynamic causal modelling and parametric empirical Bayes on rs-fMRI data to assess whether DMN changes in PDOC are caused by disruptions in the AFM. PDOC patients displayed overall reduced coupling within the AFM, and specifically, decreased self-inhibition of the striatum, paired with reduced coupling from striatum to thalamus. This led to loss of inhibition from AFM to DMN, mostly driven by posterior areas including the precuneus and inferior parietal cortex. In turn, the DMN showed disruptions in self-inhibition of the precuneus and medial prefrontal cortex. Our results provide support for the anterior mesocircuit model at the subcortical level but highlight an inhibitory role for the AFM over the DMN, which is disrupted in PDOC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.