Evidence map›Paper›PMID 34200091›Full record

ArticleBiomedicines2021

Palmitoleate Protects against Zika Virus-Induced Placental Trophoblast Apoptosis.

Philma Glora Muthuraj, Aryamav Pattnaik, Prakash K Sahoo, Md Torikul Islam, Asit K Pattnaik, Siddappa N Byrareddy, Corrine Hanson, Ann Anderson Berry, Stephen D Kachman, Sathish Kumar Natarajan

Open access · goldAbstract read
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In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Philma Glora MuthurajDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Aryamav PattnaikNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Prakash K SahooDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Md Torikul IslamDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Asit K PattnaikNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.ORCID 0000-0002-9581-6787
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-6889-4640
Corrine HansonChild Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Ann Anderson BerryChild Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-8496-2543
Stephen D KachmanDepartment of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Sathish Kumar NatarajanDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.ORCID 0000-0001-7491-8592
University of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · US

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
NIGMS NIH HHS P20 GM104320NIGMS NIH HHS P20GM104320USDA 1014526
6 · The paper itself

Abstract

Zika virus (ZIKV) infection in pregnancy is associated with the development of microcephaly, intrauterine growth restriction, and ocular damage in the fetus. ZIKV infection of the placenta plays a crucial role in the vertical transmission from the maternal circulation to the fetus. Our previous study suggested that ZIKV induces endoplasmic reticulum (ER) stress and apoptosis of placental trophoblasts. Here, we showed that palmitoleate, an omega-7 monounsaturated fatty acid, prevents ZIKV-induced ER stress and apoptosis in placental trophoblasts. Human trophoblast cell lines (JEG-3 and JAR) and normal immortalized trophoblasts (HTR-8) were used. We observed that ZIKV infection of the trophoblasts resulted in apoptosis and treatment of palmitoleate to ZIKV-infected cells significantly prevented apoptosis. However, palmitate (saturated fatty acid) did not offer protection from ZIKV-induced ER stress and apoptosis. We also observed that the Zika viral RNA copies were decreased, and the cell viability improved in ZIKV-infected cells treated with palmitoleate as compared to the infected cells without palmitoleate treatment. Further, palmitoleate was shown to protect against ZIKV-induced upregulation of ER stress markers, C/EBP homologous protein and X-box binding protein-1 splicing in placental trophoblasts. In conclusion, our studies suggest that palmitoleate protects placental trophoblasts against ZIKV-induced ER stress and apoptosis.

Indexed as

apoptosisendoplasmic reticulum stressmonounsaturated fatty acidsplacentatrophoblastviral replicationZika virus

Identifiers

PMID34200091
PMCPMC8226770
OpenAlexW3170412442

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.