Evidence map›Paper›PMID 34200068›Full record

ReviewNanomaterials (Basel, Switzerland)2021

From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.

Francisco G Blanco, Natalia Hernández, Virginia Rivero-Buceta, Beatriz Maestro, Jesús M Sanz, Aránzazu Mato, Ana M Hernández-Arriaga, M Auxiliadora Prieto

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Microbes Saving Lives and Reducing Suffering.Microbial biotechnology · 2025
    Article
  4. Article
  5. Article
  6. Enzybiotic-mediated antimicrobial functionalization of polyhydroxyalkanoates.Frontiers in bioengineering and biotechnology · 2023
    Article
  7. Review
  8. Cellulose-Based Nanomaterials Advance Biomedicine: A Review.International journal of molecular sciences · 2022
    Review
  9. Comparative Analysis of Bacterial Cellulose Membranes Synthesized by ChosenInternational journal of molecular sciences · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francisco G BlancoInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-1751-8637
Natalia HernándezInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-5416-8971
Virginia Rivero-BucetaInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-5658-1997
Beatriz MaestroHost-Parasite Interplay in Pneumococcal Infection Group, Microbial and Plant Biotechnology Department, Biological Research Centre Margarita Salas, CIB-CSIC, 28040 Madrid, Spain.
Jesús M SanzHost-Parasite Interplay in Pneumococcal Infection Group, Microbial and Plant Biotechnology Department, Biological Research Centre Margarita Salas, CIB-CSIC, 28040 Madrid, Spain.ORCID 0000-0002-4421-9376
Aránzazu MatoInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.
Ana M Hernández-ArriagaInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.
M Auxiliadora PrietoInterdisciplinary Platform for Sustainable Plastics towards a Circular Economy-Spanish National Research Council (SusPlast-CSIC), 28040 Madrid, Spain.ORCID 0000-0002-8038-1223
Consejo Superior de Investigaciones Científicas · ESCentro de Investigaciones Biológicas Margarita Salas · ES

Funding

Comunidad de Madrid P2018/NMT4389Horizon 2020 870294Ministerio de Ciencia e Innovación BiO2017- 8344-8-RMinisterio de Ciencia e Innovación PRE-2018-083859
6 · The paper itself

Abstract

Bacterial biopolymers are naturally occurring materials comprising a wide range of molecules with diverse chemical structures that can be produced from renewable sources following the principles of the circular economy. Over the last decades, they have gained substantial interest in the biomedical field as drug nanocarriers, implantable material coatings, and tissue-regeneration scaffolds or membranes due to their inherent biocompatibility, biodegradability into nonhazardous disintegration products, and their mechanical properties, which are similar to those of human tissues. The present review focuses upon three technologically advanced bacterial biopolymers, namely, bacterial cellulose (BC), polyhydroxyalkanoates (PHA), and γ-polyglutamic acid (PGA), as models of different carbon-backbone structures (polysaccharides, polyesters, and polyamides) produced by bacteria that are suitable for biomedical applications in nanoscale systems. This selection models evidence of the wide versatility of microorganisms to generate biopolymers by diverse metabolic strategies. We highlight the suitability for applied sustainable bioprocesses for the production of BC, PHA, and PGA based on renewable carbon sources and the singularity of each process driven by bacterial machinery. The inherent properties of each polymer can be fine-tuned by means of chemical and biotechnological approaches, such as metabolic engineering and peptide functionalization, to further expand their structural diversity and their applicability as nanomaterials in biomedicine.

Indexed as

bacterial cellulosebacterial polymersbiomedical applicationsbiopolymer functionalizationpolyhydroxyalkanoatesupcycled polymersγ-polyglutamic acid

Identifiers

PMID34200068
PMCPMC8228158
OpenAlexW3171521641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.