Evidence map›Paper›PMID 34200045›Full record

ArticleInternational journal of molecular sciences2021

PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke.

Jarosław Mazuryk, Izabela Puchalska, Kamil Koziński, Magdalena J Ślusarz, Jarosław Ruczyński, Piotr Rekowski, Piotr Rogujski, Rafał Płatek, Marta Barbara Wiśniewska, Arkadiusz Piotrowski and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Lasso Peptides-A New Weapon Against Superbugs.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Jarosław MazurykLaboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0003-3311-7136
Izabela PuchalskaFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-1419-4200
Kamil KozińskiLaboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-2448-687X
Magdalena J ŚlusarzFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-9411-4679
Jarosław RuczyńskiFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-1945-194X
Piotr RekowskiFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0001-6994-4833
Piotr RogujskiLaboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0003-2815-4055
Rafał PłatekLaboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0001-8850-8674
Marta Barbara WiśniewskaLaboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-1593-0361
Arkadiusz PiotrowskiDepartment of Biology and Pharmaceutical Botany, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland.ORCID 0000-0002-0823-0607
Łukasz JanusMedVentures Company, 60-141 Poznań, Poland.
Piotr M SkowronFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0003-1345-3271
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Medical University of Gdańsk, 80-210 Gdańsk, Poland.ORCID 0000-0001-7751-9781
Paweł SachadynLaboratory for Regenerative Biotechnology, Gdańsk University of Technology, 80-233 Gdańsk, Poland.ORCID 0000-0002-5087-844X
Sylwia Rodziewicz-MotowidłoFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-4471-5951
Artur CzuprynLaboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, 02-093 Warsaw, Poland.ORCID 0000-0002-3072-2114
Piotr MuchaFaculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.ORCID 0000-0002-0269-8620
University of Gdańsk · PLInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLGdańsk Medical University · PLUniversity of Warsaw · PLGdańsk University of Technology · PL

Funding

Narodowe Centrum Badań i Rozwoju STRATEGMED1/235077/9/NCBR/2014Narodowe Centrum Nauki 2015/19/B/NZ4/03571NCN
6 · The paper itself

Abstract

Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49-57)-NH

Indexed as

Disease Models, AnimalAnimalsBrain IschemiaCell Membrane PermeabilityCell-Penetrating PeptidesFemaleIschemic StrokeNeuronsNeuroprotective AgentsRatsRats, WistarCell-Penetrating PeptidesNeuroprotective Agentsarginine-rich peptidescell-penetrating peptidesexcitotoxicityischemic strokeneural viabilityneuroprotectionneurotoxicitypeptide conformationPTD4Tat(49–57)-NH2

Identifiers

PMID34200045
PMCPMC8200211
OpenAlexW3170536570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.