Evidence map›Paper›PMID 34200027›Full record

Trial reportNutrients2021

Associations of Changes in Blood Lipid Concentrations with Changes in Dietary Cholesterol Intake in the Context of a Healthy Low-Carbohydrate Weight Loss Diet: A Secondary Analysis of the DIETFITS Trial.

Monica Vergara, Michelle E Hauser, Lucia Aronica, Joseph Rigdon, Priya Fielding-Singh, Cynthia W Shih, Christopher D Gardner

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Monica VergaraDepartment of Health Research & Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michelle E HauserGeneral Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-0983-7347
Lucia AronicaStanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-8991-4858
Joseph RigdonQuantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA 94305, USA.
Priya Fielding-SinghHuntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-1085-1066
Cynthia W ShihQuantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA 94305, USA.
Christopher D GardnerStanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7596-1530
Stanford University · USUniversity of Utah · USVA Palo Alto Health Care System · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
CARDIOVASCULAR DISEASE PREVENTION TRAINING PROGRAMT32HL007034 · NHLBI · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 1985 to 2020
$8.7M
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?R01DK091831 · NIDDK · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 2012 to 2016
$3.1M
Horizon 2020 Framework Programme No 701944NCATS NIH HHS UL1 TR003142NIDDK NIH HHS 1R01DK091831NIH HHS T32HL007034NIH HHS UL1 TR001085
6 · The paper itself

Abstract

In 2015, the Dietary Guidelines for Americans (DGA) eliminated the historical upper limit of 300 mg of dietary cholesterol/day and shifted to a more general recommendation that cholesterol intake should be limited. The primary aim of this secondary analysis of the Diet Intervention Examining the Factors Interacting With Treatment Success (DIETFITS) weight loss diet trial was to evaluate the associations between 12-month changes in dietary cholesterol intake (mg/day) and changes in plasma lipids, particularly low-density lipoprotein (LDL) cholesterol for those following a healthy low-carbohydrate (HLC) diet. Secondary aims included examining high-density lipoprotein (HDL) cholesterol and triglycerides and changes in refined grains and added sugars. The DIETFITS trial randomized 609 healthy adults aged 18-50 years with body mass indices of 28-40 kg/m

Indexed as

Diet, Carbohydrate-RestrictedDiet, HealthyDiet, ReducingAdolescentAdultCholesterol, DietaryCholesterol, LDLFemaleHumansLipidsMaleMiddle AgedObesityTriglyceridesYoung AdultCholesterol, DietaryCholesterol, LDLLipidsTriglyceridesdietary cholesteroldiet qualityeggsHDL cholesterolhealthy adultshuman studyLDL cholesterollow-carbohydratetriglyceridesweight loss trial

Identifiers

PMID34200027
PMCPMC8227338
OpenAlexW3166563463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.