ArticleMolecules (Basel, Switzerland)2021
An Investigation into the Potential of Targeting
Layla R Goddard, Charlotte E Mardle, Hassan Gneid, Ciara G Ball, Darren M Gowers, Helen S Atkins, Louise E Butt, Jonathan K Watts, Helen A Vincent, Anastasia J Callaghan
Open access · goldAbstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 2 countries.
Layla R GoddardSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Charlotte E MardleSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Hassan GneidRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01609, USA.ORCID 0000-0001-9326-2023 Ciara G BallSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Darren M GowersSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.ORCID 0000-0001-7604-012X Helen S AtkinsDefence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
Louise E ButtSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Jonathan K WattsRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01609, USA.
Helen A VincentSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Anastasia J CallaghanSchool of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
University of Portsmouth · GBUniversity of Massachusetts Chan Medical School · USDefence Science and Technology Laboratory · GB
Funding
Biotechnology and Biological Sciences Research Council (BBSRC) BB/M020576/1Defence Science and Technology Laboratory PhD studentshipEngineering and Physical Sciences Research Council (EPSRC) iCASE award with DstlResearch England E3 FundingUniversity of Massachusetts Medical School N/A
6 · The paper itselfAbstract
The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies. RNA degradation and ribonucleases, such as the essential endoribonuclease RNase E, encoded by the
Indexed as
Anti-Bacterial AgentsCell-Free SystemEndoribonucleasesEscherichia coliEscherichia coli ProteinsOligonucleotidesPeptide Chain Initiation, TranslationalRNA, MessengerAnti-Bacterial AgentsEndoribonucleasesEscherichia coli Proteinslocked nucleic acidOligonucleotidesribonuclease ERNA, Messengerantibacterialantisense oligonucleotidegapmerlocked nucleic acid (LNA)RNase ERNase Hrne mRNAtranslation blocking
Identifiers
PMID34200016
PMCPMC8200214
OpenAlexW3166569684
What OpenQuestion holds
Textmetadata
LicenceCC BY
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