Evidence map›Paper›PMID 34199944›Full record

ArticleCells2021

Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation.

Laura Jankó, Tünde Kovács, Miklós Laczik, Zsanett Sári, Gyula Ujlaki, Gréta Kis, Ibolya Horváth, Miklós Antal, László Vígh, Bálint L Bálint and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. PARP-1 negatively regulates nucleolar protein pool and mitochondrial activity: a cell protective mechanism.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura JankóDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Tünde KovácsDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Miklós LaczikDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Zsanett SáriDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Gyula UjlakiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Gréta KisDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Ibolya HorváthBiological Research Center of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
Miklós AntalDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
László VíghBiological Research Center of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
Bálint L BálintDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-6163-7190
Karen UrayDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0001-6997-459X
Péter BaiDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-6191-6616

Funding

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal 123975Nemzeti Kutatási Fejlesztési és Innovációs Hivatal EFOP-3.6.2-16-2017-00006Nemzeti Kutatási Fejlesztési és Innovációs Hivatal GINOP-2.3.2-15-2016-00006Nemzeti Kutatási Fejlesztési és Innovációs Hivatal NKFIH-1150-6/2019Nemzeti Kutatási Fejlesztési és Innovációs Hivatal ÚNKP-20-4-II-DE-68
6 · The paper itself

Abstract

PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD

Indexed as

Gene SilencingMitochondriaPoly(ADP-ribose) PolymerasesHep G2 CellsHumansMitochondrial DynamicsReactive Oxygen SpeciesSirtuin 1PARP2 protein, humanPoly(ADP-ribose) PolymerasesReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1ARTD2mitochondrial biogenesismitochondrial fragmentationmitochondrial morphologyoxidative stressPARP2skeletal muscle

Identifiers

PMID34199944
PMCPMC8227884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.