Evidence map›Paper›PMID 34199863›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Accumulation of Seminolipid in Sertoli Cells Is Associated with Increased Levels of Reactive Oxygen Species and Male Subfertility: Studies in Aging

Kessiri Kongmanas, Arpornrad Saewu, Wongsakorn Kiattiburut, Mark A Baker, Kym F Faull, Dylan Burger, Nongnuj Tanphaichitr

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025
    Review
  10. Article
  11. Ether lipids and a peroxisomal riddle in sperm.Frontiers in cell and developmental biology · 2023
    Review
  12. Antioxidants and Male Infertility.Antioxidants (Basel, Switzerland) · 2022
    Article
  13. Testicular aging, male fertility and beyond.Frontiers in endocrinology · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Kessiri KongmanasChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-5937-7254
Arpornrad SaewuChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-5346-025X
Wongsakorn KiattiburutChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Mark A BakerDepartment of Biological Science, University of Newcastle, Callaghan, NSW 2308, Australia.
Kym F FaullPasarow Mass Spectrometry Laboratory, University of California, Los Angeles, CA 90024, USA.
Dylan BurgerChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0003-3951-2911
Nongnuj TanphaichitrChronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-8585-6670
Ottawa Hospital · CAUniversity of Ottawa · CASiriraj Hospital · THUniversity of California, Los Angeles · USUniversity of Newcastle Australia · AU

Funding

CIHR MOP 119438
6 · The paper itself

Abstract

Seminolipid (also known as sulfogalactosylglycerolipid-SGG), present selectively in male germ cells, plays important roles in spermatogenesis and sperm-egg interaction. The proper degradation of SGG in apoptotic germ cells is also as important. Sertoli cells first phagocytose apoptotic germ cells, then Sertoli lysosomal arylsulfatase A (ARSA) desulfates SGG, the first step of SGG degradation. We have reported that aging male

Indexed as

arylsulfatase Amale fertilityoxidative stressreactive oxygen speciesseminolipidSertoli cellssperm qualitystorage diseasessulfogalactosylglycerolipidtesticular germ cells

Identifiers

PMID34199863
PMCPMC8227610
OpenAlexW3168663200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.