Evidence map›Paper›PMID 34199852›Full record

ArticlePathogens (Basel, Switzerland)2021

Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population.

Ana Méndez-Echevarría, Talía Sainz, Iker Falces-Romero, Beatriz de Felipe, Lucia Escolano, Sonia Alcolea, Lidia Pertiñez, Olaf Neth, Cristina Calvo

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Observational
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  15. Respiratory Tract Infections in Children.Pathogens (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Méndez-EchevarríaPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.ORCID 0000-0002-7455-9080
Talía SainzPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.ORCID 0000-0002-5301-0945
Iker Falces-RomeroMicrobiology Department, La Paz University Hospital, 28049 Madrid, Spain.ORCID 0000-0001-5888-7706
Beatriz de FelipePediatrics, Infectious Diseases, Rheumatology and Immunology Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.
Lucia EscolanoPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.
Sonia AlcoleaPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.
Lidia PertiñezPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.
Olaf NethPediatrics, Infectious Diseases, Rheumatology and Immunology Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.
Cristina CalvoPediatrics and Infectious Disease Unit, La Paz University Hospital, Translational Research Network of Pediatric Infectious Diseases (RITIP), 28049 Madrid, Spain.ORCID 0000-0002-6503-3423

Funding

Merck Sharp and Dohme MISP Call, Reference # 60465
6 · The paper itself

Abstract

backgroundAntibody dynamics over time after SARS-CoV-2 infection are still unclear, and data regarding children are scarce.

methodsA prospective cohort study was performed including children infected by SARS-CoV-2 between March and May 2020. Patients were categorized into 3 groups: children admitted with COVID-19; outpatient children with mild COVID-19; and seropositive children participating in a seroprevalence study among cohabitants of infected healthcare workers (HCWs). Six months after the infection, a new serological control was performed.

resultsA total of 58 children were included, 50% male (median age 8.3 [IQR 2.8-13.5] years). The median time between the two serological studies was 186 (IQR 176-192) days, and 86% (48/56) of the children maintained positive IgG six months after the infection. This percentage was 100% in admitted patients and 78% among the rest of the included children (

conclusionsMost children infected by SARS-CoV-2 maintain a positive serological response six months after the infection. Those children who lost their IgG titer were more frequently asymptomatic or mildly symptomatic, presenting with low antibody titers after the infection.

Indexed as

antibodychildrenCOVID-19pediatricSARS-CoV-2serology

Identifiers

PMID34199852
PMCPMC8226775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.