Evidence map›Paper›PMID 34199843›Full record

ArticleCells2021

Interference of LPS

Weronika Gonciarz, Agnieszka Krupa, Anthony P Moran, Agata Tomaszewska, Magdalena Chmiela

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. HistologicalDEN open · 2027
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  2. Recent advances in spasmolytic polypeptide expressing metaplasia research.World journal of gastrointestinal oncology · 2026
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  10. Flavonoid-RichInternational journal of molecular sciences · 2023
    Article
  11. Reactive Oxygen Species andAntioxidants (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. CagA and VacA inhibit gastric mucosal epithelial cell autophagy and promote the progression of gastric precancerous lesions.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Weronika GonciarzDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha Str. 12/16, 90-237 Lodz, Poland.ORCID 0000-0002-5231-5341
Agnieszka KrupaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha Str. 12/16, 90-237 Lodz, Poland.
Anthony P MoranDepartment of Microbiology, School of Natural Sciences, National University of Ireland Galway, SW4 Galway, Ireland.
Agata TomaszewskaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha Str. 12/16, 90-237 Lodz, Poland.
Magdalena ChmielaDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha Str. 12/16, 90-237 Lodz, Poland.
University of Łódź · PLOllscoil na Gaillimhe – University of Galway · IE

Funding

Uniwersytet Łódzki 25/IDUB/MLOD/2021 (B2111001000027.07)
6 · The paper itself

Abstract

backgroundLipopolysaccharide (LPS) of

aimTo elucidate whether Hp LPS affects regeneration of gastric barrier initiated by IL-33.

methodsPrimary gastric epithelial cells or fibroblasts from

resultsControl cells not treated with LPS Hp migrated in the presence of IL-33. The pro-regenerative activity of IL-33 was related to stimulation of cells to collagen I production. Wound healing by cells exposed to LPS Hp was inhibited even in the presence of IL-33. This could be due to increased oxidative stress and apoptosis in conjunction with Erk activation, sST2 elevation and modulation of collagen I production.

conclusionsThe recovery of gastric barrier cells during Hp infection potentially can be affected due to downregulation of pro-regenerative activity of IL-33 by LPS Hp.

Indexed as

AnimalsEpithelial CellsFibroblastsGastric MucosaGuinea PigsHelicobacter pyloriInterleukin-33LipopolysaccharidesRegenerationInterleukin-33Lipopolysaccharidescollagen IHelicobacter pyloriIL-33LPSregenerationST2

Identifiers

PMID34199843
PMCPMC8227243
OpenAlexW3167962825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.