Trial reportNutrients2021
Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Dietary interventions in cancer: a systematic review of all randomized controlled trials.Journal of the National Cancer Institute · 2024Pooled it
- Has a High Dose of Vitamin D3 Impacted Health Conditions in Older Adults?-A Systematic Review and Meta-Analysis Focusing on Dose 100,000 IU.Nutrients · 2024Pooled it
- Post-Diagnosis Vitamin D Supplement Use and Survival among Cancer Patients: A Meta-Analysis.Nutrients · 2022Pooled it
- The Role of Vitamins and Micronutrients in the Prevention of Melanoma: A Review of Current Evidence.International journal of molecular sciences · 2026Review
- Vitamin D and the aging skin: insights into oxidative stress, inflammation, and barrier function.Immunity & ageing : I & A · 2025Review
- Review
- Primary Cutaneous Melanoma-Management in 2024.Journal of clinical medicine · 2024Article
- Review
- Review
- Vitamin D Modulates the Response of Patient-Derived Metastatic Melanoma Cells to Anticancer Drugs.International journal of molecular sciences · 2023Article
- Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours.Frontiers in oncology · 2023Article
- The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.Antioxidants (Basel, Switzerland) · 2022Review
- Vitamin DFrontiers in pharmacology · 2022Article
- The Chemoprotective Role of Vitamin D in Skin Cancer: A Systematic Review.Cancer management and research · 2022Review
- Review
- Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 9 institutions in 2 countries.
Harriet JohanssonDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-4131-2030
Giuseppe SpadolaDivisione di Chirurgia del Melanoma, IRCCS Fondazione Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy.ORCID 0000-0001-5203-9503
Giulio TostiDivision of Surgery for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0001-8231-2814
Mario MandalàUnit of Medical Oncology, Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, 24127 Bergamo, Italy.
Alessandro M MinisiniDepartment of Oncology, Azienda Sanitaria Universitaria del Friuli Centrale, 33100 Udine, Italy.
Paola QueiroloDepartment of Medical Oncology, IRCCS Ospedale Policlinico San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy.
Valentina AristarcoDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-4939-6240
Federica BaldiniDivision of Surgery for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Emilia CocorocchioDivision of Medical Oncology for Melanoma, Sarcoma and Rare Tumors, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Elena AlbertazziSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Leonardo ZichichiDermatology Unit, Ospedale S.A. Abate, 91016 Erice, Italy.
Saverio CinieriMedical Oncology & Breast Unit, Department of Oncology, "Antonio Perrino" Hospital, 72100 Brindisi, Italy.
Costantino JemosDivision of Pharmacy, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Giovanni MazzarolDivision of Pathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Patrizia GnagnarellaDivision of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-0560-4706
Debora MacisDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-0633-2933
Ines TedeschiDivision of Surgery for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Emanuela Omodeo SalèDivision of Pharmacy, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Luigia Stefania StucciSection of Medical Oncology, Department of Biomedical Sciences and Clinical Oncology (DIMO), University of Bari 'Aldo Moro', 70124 Bari, Italy.ORCID 0000-0003-2063-1435
Bernardo BonanniDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0003-3589-2128
Alessandro TestoriEORTC Melanoma Group, 1200 Brussel, Belgium.
Elisabetta PennacchioliDivision of Surgery for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Pier Francesco FerrucciBiotherapy of Tumors Unit, IEO, Department of Experimental Oncology, European Institute of Oncology, IRCCS, 20141 Milan, Italy.ORCID 0000-0001-6255-5851
Sara GandiniDepartment of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0002-1348-4548
On Behalf Of The Italian Melanoma Intergroup Imi
European Institute of Oncology · ITEuropean Organisation for Research and Treatment of Cancer · BEFondazione IRCCS Istituto Nazionale dei Tumori · ITOspedale A. Perrino · ITOspedale Papa Giovanni XXIII · ITOspedale Policlinico San Martino · ITOspedale Santa Maria della Misericordia di Udine · ITThe San Raffaele Telethon Institute for Gene Therapy · ITUniversity of Bari Aldo Moro · IT
Funding
Fondazione Umberto Veronesi not availableItalian Ministry of Health with Ricerca Corrente and 5x1000 funds not available
Abstract
Patients with newly resected stage II melanoma (
Indexed as
Dietary SupplementsAgedCholecalciferolDisease-Free SurvivalFemaleHumansMaleMelanomaMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingSkin NeoplasmsVitaminsCholecalciferolVitaminsBreslowcancermelanomaprognosissingle-nucleotide polymorphismsvitamin D
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.