Mutations in

Negin Malekian, Ali Al-Fatlawi, Thomas U Berendonk, Michael Schroeder

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.3field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

A comparative genomic approach to identify determinants of meropenem resistance inFrontiers in microbiology · 2026
Article
Bacterial genome-wide association studies: exploring the genetic variation underlying bacterial phenotypes.Applied and environmental microbiology · 2025
Review
Genome-Wide Association Studies (GWAS) Approaches for the Detection of Genetic Variants Associated with Antibiotic Resistance: A Systematic Review.Microorganisms · 2023
Review
Word-based GWAS harnesses the rich potential of genomic data forFrontiers in microbiology · 2023
Article
A genome-wide scan of wastewater E. coli for genes under positive selection: focusing on mechanisms of antibiotic resistance.Scientific reports · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Negin MalekianBiotechnology Center (BIOTEC), Dresden University of Technology, Tatzberg 47-49, 01307 Dresden, Germany.

Ali Al-FatlawiBiotechnology Center (BIOTEC), Dresden University of Technology, Tatzberg 47-49, 01307 Dresden, Germany.

Thomas U BerendonkInstitute of Hydrobiology, Dresden University of Technology, 01217 Dresden, Germany.

Michael SchroederBiotechnology Center (BIOTEC), Dresden University of Technology, Tatzberg 47-49, 01307 Dresden, Germany.

TU Dresden · DE

Funding

Bundesministerium für Bildung und Forschung acras-r

6 · The paper itself

Abstract

Single mutations can confer resistance to antibiotics. Identifying such mutations can help to develop and improve drugs. Here, we systematically screen for candidate quinolone resistance-conferring mutations. We sequenced highly diverse wastewater

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsGenetic LociGenome-Wide Association StudyLinkage DisequilibriumModels, MolecularMutationPhenotypePhylogenyQuinolonesValine-tRNA LigaseWastewaterAnti-Bacterial AgentsBdcA protein, E coliEscherichia coli ProteinsQuinolonesValine-tRNA LigasevalS protein, E coliWastewaterantibiotic resistanceE. coligenome-wide association study (GWAS)quinolones

Identifiers

PMID34199768

DOI10.3390/ijms22116063

PMCPMC8200043

OpenAlexW3130937374

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.