Evidence map›Paper›PMID 34199597›Full record

ArticleMolecules (Basel, Switzerland)2021

Gossypitrin, A Naturally Occurring Flavonoid, Attenuates Iron-Induced Neuronal and Mitochondrial Damage.

María Ángeles Bécquer-Viart, Adonis Armentero-López, Daniel Alvarez-Almiñaque, Roberto Fernández-Acosta, Yasser Matos-Peralta, Richard F D'Vries, Javier Marín-Prida, Gilberto L Pardo-Andreu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Neurotrophic Natural Products.Progress in the chemistry of organic natural products · 2024
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

María Ángeles Bécquer-ViartCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/ 23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.
Adonis Armentero-LópezCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/ 23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.
Daniel Alvarez-AlmiñaqueCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/ 23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.
Roberto Fernández-AcostaPharmacy Department, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.ORCID 0000-0002-1588-9231
Yasser Matos-PeraltaBioinorganic Laboratory, Faculty of Chemistry, University of Havana, Zapata and G, Vedado, La Habana CP 10400, Cuba.ORCID 0000-0003-4116-4987
Richard F D'VriesFacultad de Ciencias Básicas, Universidad Santiago de Cali, Calle 5 # 62-00, Cali CP 76001, Colombia.ORCID 0000-0002-3655-1838
Javier Marín-PridaCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/ 23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.
Gilberto L Pardo-AndreuCenter for Research and Biological Evaluations, Institute of Pharmaceutical and Food Sciences, University of Havana, 222 St. #2317 b/ 23 and 31, La Coronela, La Lisa, La Habana CP 13600, Cuba.ORCID 0000-0001-7040-7031
University of Havana · CUUniversidad Santiago de Cali · CO

Funding

Ministerio de Ciencia, Tecnología y Medio Ambiente de Cuba PN223LH010-035Vlaamse Interuniversitaire Raad CU2018TEA457A103
6 · The paper itself

Abstract

The disruption of iron homeostasis is an important factor in the loss of mitochondrial function in neural cells, leading to neurodegeneration. Here, we assessed the protective action of gossypitrin (Gos), a naturally occurring flavonoid, on iron-induced neuronal cell damage using mouse hippocampal HT-22 cells and mitochondria isolated from rat brains. Gos was able to rescue HT22 cells from the damage induced by 100 µM Fe(II)-citrate (EC

Indexed as

Adenosine TriphosphateAnimalsCell LineCell SurvivalCitric AcidFerrous CompoundsFlavonoidsIronLipid PeroxidationMaleMembrane Potential, MitochondrialMiceMitochondriaNeuronsRatsAdenosine TriphosphateCitric Acidferrous citrateFerrous CompoundsFlavonoidsgossypitrinIrongossypitrinHT-22 cellsironmitochondrianeurodegenerationneuroprotection

Identifiers

PMID34199597
PMCPMC8199700
OpenAlexW3168411338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.