Evidence map›Paper›PMID 34199488›Full record

ArticleMolecules (Basel, Switzerland)2021

Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M

Ibrahim Seyda Uras, Sherif S Ebada, Michal Korinek, Amgad Albohy, Basma S Abdulrazik, Yi-Hsuan Wang, Bing-Hung Chen, Jim-Tong Horng, Wenhan Lin, Tsong-Long Hwang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Ibrahim Seyda UrasDepartment of Pharmacognosy, Faculty of Pharmacy, Ankara University, Ankara 06560, Turkey.
Sherif S EbadaDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbasia, Cairo 11566, Egypt.ORCID 0000-0002-2753-0031
Michal KorinekGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0002-8988-8610
Amgad AlbohyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, Suez Desert Road, Cairo 11837, Egypt.ORCID 0000-0003-3021-8767
Basma S AbdulrazikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, Suez Desert Road, Cairo 11837, Egypt.
Yi-Hsuan WangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Bing-Hung ChenDepartment of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0001-5960-5176
Jim-Tong HorngDepartment of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Wenhan LinState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.ORCID 0000-0002-4978-4083
Tsong-Long HwangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-5780-3977
Belma KonuklugilDepartment of Pharmacognosy, Faculty of Pharmacy, Ankara University, Ankara 06560, Turkey.
Ankara University · TRBritish University in Egypt · EGChang Gung University · TWAin Shams University · EGChang Gung University of Science and Technology · TWMing Chi University of Technology · TWNational Sun Yat-sen University · TWPeking University · CN

Funding

Chang Gung Memorial Hospital CMRPF1G0241~3, CMRPF1J0051~3, and BMRP450Chang Gung University 104-6576A3Ministry of Science and Technology MOST 106-2320-B-255-003-MY3 and MOST 108-2320-B-255-003-MY3, MOST 109-2327-B-255-001, and MOST 109-2327-B-182-002TUBİTAK-BMBF 114S916
6 · The paper itself

Abstract

In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing. Although several other mutants were previously reported, VUI-202012/01 proved to be about 70% more transmissible. Hence, the usefulness and effectiveness of the newly U.S. Food and Drug Administration (FDA)-approved COVID-19 vaccines against these new variants are doubtfully questioned. As a result of these unexpected mutants from COVID-19 and due to lack of time, much research interest is directed toward assessing secondary metabolites as potential candidates for developing lead pharmaceuticals. In this study, a marine-derived fungus

Indexed as

4-ButyrolactoneAnti-Allergic AgentsAnti-Inflammatory AgentsAspergillusBinding SitesCatalytic DomainCoronavirus M ProteinsCOVID-19HumansLeukocyte ElastaseMagnetic Resonance SpectroscopyMolecular ConformationMolecular Docking SimulationNeutrophilsSARS-CoV-2Seawater4-ButyrolactoneAnti-Allergic AgentsAnti-Inflammatory AgentsbutenolideCoronavirus M ProteinsLeukocyte Elastasemembrane protein, SARS-CoV-2Viral Matrix ProteinsantiallergicAspergillus terreusbutenolidesCOVID-19 Mproelastase

Identifiers

PMID34199488
PMCPMC8199578
OpenAlexW3167591395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.