Evidence map›Paper›PMID 34199456›Full record

ArticleViruses2021

Molecular Characterization of Highly Pathogenic Avian Influenza Viruses H5N6 Detected in Denmark in 2018-2019.

Yuan Liang, Jesper Schak Krog, Pia Ryt-Hansen, Anders Gorm Pedersen, Lise Kirstine Kvisgaard, Elisabeth Holm, Pernille Dahl Nielsen, Anne Sofie Hammer, Jesper Johannes Madsen, Kasper Thorup and 2 more

Open access · goldAbstract readHistorical Article
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Avian Influenza: Strategies to Manage an Outbreak.Pathogens (Basel, Switzerland) · 2023
    Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yuan LiangDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.
Jesper Schak KrogDepartment of Virus and Microbiological Special Diagnostics, Statens Serum Institut, 2300 Copenhagen S, Denmark.
Pia Ryt-HansenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.
Anders Gorm PedersenDTU Health Tech, Bioinformatics, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
Lise Kirstine KvisgaardDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.
Elisabeth HolmDepartment of Virus and Microbiological Special Diagnostics, Statens Serum Institut, 2300 Copenhagen S, Denmark.
Pernille Dahl NielsenAnimal Health Division, Danish Veterinary and Food Administration, 2600 Glostrup, Denmark.
Anne Sofie HammerDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.
Jesper Johannes MadsenNatural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark.
Kasper ThorupGLOBE Institute, University of Copenhagen, 1350 Copenhagen, Denmark.ORCID 0000-0002-0320-0601
Lars Erik LarsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.ORCID 0000-0003-0730-5555
Charlotte Kristiane HjulsagerDepartment of Virus and Microbiological Special Diagnostics, Statens Serum Institut, 2300 Copenhagen S, Denmark.ORCID 0000-0001-7557-8876
University of Copenhagen · DKStatens Serum Institut · DKDanish Agriculture and Food Council · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beginning in late 2017, highly pathogenic avian influenza (HPAI) H5N6 viruses caused outbreaks in wild birds and poultry in several European countries. H5N6 viruses were detected in 43 wild birds found dead throughout Denmark. Most of the Danish virus-positive dead birds were found in the period from February to April 2018. However, unlike the rest of Europe, sporadic HPAI H5N6-positive dead wild birds were detected in Denmark in July, August, September, and December 2018, with the last positive bird being found in January 2019. HPAI viruses were not detected in active surveillance of apparently healthy wild birds. In this study, we use full genome sequencing and phylogenetic analysis to investigate the wild bird HPAI H5N6 viruses found in Denmark. The Danish viruses were found to be closely related to those of contemporary HPAI H5N6 viruses detected in Europe. Their sequences formed two clusters indicating that at least two or more introductions of H5N6 into Denmark occurred. Notably, all viruses detected in the latter half of 2018 and in 2019 grouped into the same cluster. The H5N6 viruses appeared to have been maintained undetected in the autumn 2018.

Indexed as

AnimalsAnimals, WildBayes TheoremBirdsDenmarkDisease OutbreaksEvolution, MolecularGeography, MedicalHistory, 21st CenturyInfluenza A virusInfluenza in BirdsPhylogenyPublic Health SurveillanceRNA, ViralRNA, Viralbirdsdisease outbreaksEuropaH5N6 subtypehighly pathogenic avian influenzainfectious disease outbreakinfluenza A virusphylogenysurveillancewild

Identifiers

PMID34199456
PMCPMC8226499
OpenAlexW3171366575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.