Evidence map›Paper›PMID 34199418›Full record

ReviewMolecules (Basel, Switzerland)2021

Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor.

Jieon Lee, Diana Avramets, Byungsun Jeon, Hyunah Choo

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. The Importance of Stereochemistry in 5-HTACS chemical neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Epigenetics in rare neurological diseases.Frontiers in cell and developmental biology · 2024
    Review
  12. Development of a 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Design and discovery of a high affinity, selective and β-arrestin biased 5-HTMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jieon LeeBrain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Korea.
Diana AvrametsBrain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Korea.ORCID 0000-0001-5278-1652
Byungsun JeonBrain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Korea.
Hyunah ChooBrain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Korea.
Korea Institute of Brain Science · KR

Funding

Korea Institute of Science and Technology 2E30961 and 2E30960National Research Foundation of Korea NRF-2021R1A2C2006244 and NRF-2016M3C7A1904344
6 · The paper itself

Abstract

Since neurodevelopmental disorders (NDDs) influence more than 3% of children worldwide, there has been intense investigation to understand the etiology of disorders and develop treatments. Although there are drugs such as aripiprazole, risperidone, and lurasidone, these medications are not cures for the disorders and can only help people feel better or alleviate their symptoms. Thus, it is required to discover therapeutic targets in order to find the ultimate treatments of neurodevelopmental disorders. It is suggested that abnormal neuronal morphology in the neurodevelopment process is a main cause of NDDs, in which the serotonergic system is emerging as playing a crucial role. From this point of view, we noticed the correlation between serotonin receptor subtype 7 (5-HT

Indexed as

AnimalsHumansMolecular Targeted TherapyNeurodevelopmental DisordersReceptors, SerotoninSerotonin AntagonistsSerotonin Receptor AgonistsSignal TransductionReceptors, Serotoninserotonin 7 receptorSerotonin AntagonistsSerotonin Receptor Agonists5-HT7Rautism spectrum disorderfragile X syndromeneurodevelopmental disordersRett syndromeserotonin receptor

Identifiers

PMID34199418
PMCPMC8199608
OpenAlexW3166562976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.