Evidence map›Paper›PMID 34199400›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Alpha2-Adrenoblockers Regulate Development of Oxidative Stress and Cognitive Behaviour of Rats under Chronic Acoustic Stress Conditions.

Magdalina Melkonyan, Ashkhen Manukyan, Lilit Hunanyan, Artem Grigoryan, Hayk Harutyunyan, Lilit Sukiasyan, Lusine Danielyan, Konstantin Yenkoyan

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Noise as a cause of neurodegenerative disorders: molecular and cellular mechanisms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Magdalina MelkonyanDepartment of Medical Chemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Ashkhen ManukyanDepartment of Medical Chemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Lilit HunanyanDepartment of Medical Chemistry, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Artem GrigoryanDepartment of Pathophysiology, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.ORCID 0000-0002-8799-4882
Hayk HarutyunyanLaboratory of Neuroscience, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Lilit SukiasyanLaboratory of Morphological Studies, SRS, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Lusine DanielyanDepartment of Clinical Pharmacology, University Hospital of Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0003-4130-8477
Konstantin YenkoyanLaboratory of Neuroscience, Yerevan State Medical University after M. Heratsi, Yerevan 0025, Armenia.
Yerevan State Medical University · AM

Funding

EU funded H2020 COBRAIN project 857600State Committee of Science RA N 10-14/I-1
6 · The paper itself

Abstract

Noise is a wide-spread stress factor in modern life produced by urbanization, traffic, and an industrialized environment. Noise stress causes dysfunction and neurotransmission impairment in the central nervous system, as well as changes in hormone levels. In this study, we have examined the level of α-Tocopherol (α-T) and malondialdehyde (MDA) in plasma and the erythrocytes' membrane (EM), as well as the behavioral characteristics of a noise-induced stress model in rats. In addition, the modulating effect of α

Indexed as

anxiety-related behaviormalondialdehydenoiseoxidative stressα2-adrenoblockersα-Tocopherol

Identifiers

PMID34199400
PMCPMC8228817
OpenAlexW3168976904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.