Evidence map›Paper›PMID 34199384›Full record

ReviewVaccines2021

Comparison and Analysis of Neutralizing Antibody Levels in Serum after Inoculating with SARS-CoV-2, MERS-CoV, or SARS-CoV Vaccines in Humans.

Sicong Yu, Keda Chen, Lei Fang, Haiyan Mao, Xiuyu Lou, Chaonan Li, Yanjun Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sicong YuSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Keda ChenShulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China.ORCID 0000-0002-9469-0991
Lei FangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Haiyan MaoZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Xiuyu LouZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Chaonan LiShulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China.ORCID 0000-0002-5514-842X
Yanjun ZhangZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Zhejiang Center for Disease Control and Prevention · CNZhejiang Shuren University · CNZhejiang Chinese Medical University · CN

Funding

Health leading Talents Program of Zhejiang Province CX-9Key Research and Development Program of Zhejiang Province 2021C03044Major Health Science and Technology Projects of Zhejiang Province WKJ-ZJ-2105
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) pose a great threat to humanity. Every pandemic involving these coronaviruses has seriously affected human health and economic development. Currently, there are no approved therapeutic drugs against their infections. Therefore, the development of vaccines is particularly important to combat these coronaviruses. In this review, we summarized and analyzed the progress of vaccines against SARS-CoV, MERS-CoV, and SARS-CoV-2, including inactivated vaccines, live attenuated vaccines, subunit vaccines, nucleic acid vaccines, and viral vector vaccines. In addition, we compared the levels of neutralizing antibodies in the serum of patients with these three kinds of coronaviruses at different stages, and their ability and effects against SARS-CoV-2, MERS-CoV, and SARS-CoV. This review provides useful information for vaccine evaluation and analysis.

Indexed as

MERS-CoVneutralizing antibodySARS-CoVSARS-CoV-2vaccine

Identifiers

PMID34199384
PMCPMC8229804
OpenAlexW3170224888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.