Evidence map›Paper›PMID 34199380›Full record

ArticleMedicina (Kaunas, Lithuania)2021

Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip.

Giovanni Pentangelo, Steven Paul Nisticò, Eugenio Provenzano, Giusy Ylenia Cisale, Luigi Bennardo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. FMISO-Based Adaptive Radiotherapy in Head and Neck Cancer.Journal of personalized medicine · 2022
    Review
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  7. Article
  8. Review
  9. Review
  10. Sequential Use of COMedicina (Kaunas, Lithuania) · 2022
    Article
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  13. Article
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  15. Article
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  18. Article
  19. Anti-Melanoma Capability of Contactless Cold Atmospheric Plasma Treatment.International journal of molecular sciences · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Giovanni PentangeloUnit of Oral Surgery, Polla Hospital, 84035 Polla, Italy.
Steven Paul NisticòDepartment of Health Sciences, Magna Graecia University, Viale Europa, SNC, 88100 Catanzaro, Italy.
Eugenio ProvenzanoUnit of Dermatology, Annunziata Hospital, 87100 Cosenza, Italy.
Giusy Ylenia CisaleDepartment of Physiology and Pharmacology, Sapienza University of Rome, 00100 Rome, Italy.
Luigi BennardoDepartment of Health Sciences, Magna Graecia University, Viale Europa, SNC, 88100 Catanzaro, Italy.ORCID 0000-0002-0434-1027
Magna Graecia University · ITOspedale Annunziata di Cosenza · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSquamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection. CASE REPORT: In this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred.

conclusionsTopical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.

Indexed as

Carcinoma, Squamous CellPapillomavirus InfectionsAged, 80 and overHumansImiquimodLipNeoplasm Recurrence, LocalImiquimodhead and neck cancerHPVSCCtopical imiquimod

Identifiers

PMID34199380
PMCPMC8227566
OpenAlexW3170419882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.