Evidence map›Paper›PMID 34199341›Full record

ArticleMaterials (Basel, Switzerland)2021

Boron-Rich Boron Carbide Nanoparticles as a Carrier in Boron Neutron Capture Therapy: Their Influence on Tumor and Immune Phagocytic Cells.

Dawid Kozień, Bożena Szermer-Olearnik, Andrzej Rapak, Agnieszka Szczygieł, Natalia Anger-Góra, Janusz Boratyński, Elżbieta Pajtasz-Piasecka, Mirosław M Bućko, Zbigniew Pędzich

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  3. International journal of molecular sciences · 2025
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dawid KozieńFaculty of Materials Science and Ceramics, AGH University of Science and Technology, 30 Mickiewicz Av., 30-059 Kraków, Poland.ORCID 0000-0002-5358-0809
Bożena Szermer-OlearnikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0002-1451-4227
Andrzej RapakHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0003-4897-0287
Agnieszka SzczygiełHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0003-1516-5636
Natalia Anger-GóraHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0003-4942-9134
Janusz BoratyńskiHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Elżbieta Pajtasz-PiaseckaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.ORCID 0000-0002-0253-970X
Mirosław M BućkoFaculty of Materials Science and Ceramics, AGH University of Science and Technology, 30 Mickiewicz Av., 30-059 Kraków, Poland.
Zbigniew PędzichFaculty of Materials Science and Ceramics, AGH University of Science and Technology, 30 Mickiewicz Av., 30-059 Kraków, Poland.

Funding

National Science Center, Poland UMO-2019/33/B/NZ5/02212Polish State Ministry of Education and Science for AGH University of Science and Technology, Faculty of Materials Science and Ceramics 16.16.160.557
6 · The paper itself

Abstract

The aim of the work was to study the interaction between boron-rich boron carbide nanoparticles and selected tumor and immune phagocytic cells. Experiments were performed to investigate the feasibility of the application of boron carbide nanoparticles as a boron carrier in boron neutron capture therapy. Boron carbide powder was prepared by the direct reaction between boron and soot using the transport of reagents through the gas phase. The powder was ground, and a population of nanoparticles with an average particle size about 80 nm was selected by centrifugation. The aqueous suspension of the nanoparticles was functionalized with human immunoglobulins or FITC-labeled human immunoglobulins and was then added to the MC38 murine colon carcinoma and to the RAW 264.7 cell line of mouse macrophages. Flow cytometry analysis was used to determine interactions between the functionalized boron carbide nanoparticles and respective cells. It was shown that B

Indexed as

boron neutron capture therapyboron-rich boron carbide nanoparticlesfunctionalization

Identifiers

PMID34199341
PMCPMC8199563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.