Evidence map›Paper›PMID 34199237›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study.

Nuria Perez-Diaz-Del-Campo, Jose I Riezu-Boj, Bertha Araceli Marin-Alejandre, J Ignacio Monreal, Mariana Elorz, José Ignacio Herrero, Alberto Benito-Boillos, Fermín I Milagro, Josep A Tur, Itziar Abete and 2 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nuria Perez-Diaz-Del-CampoDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-0479-8825
Jose I Riezu-BojCentre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-1885-8457
Bertha Araceli Marin-AlejandreDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-0741-8197
J Ignacio MonrealNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
Mariana ElorzNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
José Ignacio HerreroNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
Alberto Benito-BoillosNavarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
Fermín I MilagroDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-3228-9916
Josep A TurBiomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-6940-0761
Itziar AbeteDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-6475-5387
M Angeles ZuletDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-3926-0892
J Alfredo MartinezDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-5218-6941
Instituto de Salud Carlos III · ESNavarre Institute of Health Research · ESUniversidad de Navarra · ES

Funding

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición CB12/03/3002Fundació la Marató de TV3 201630.10Health Department of the Government of Navarra 61/2015
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this investigation was to assess genetic and non-genetic determinants putatively involved in the onset and progression of NAFLD after a 6-month weight loss nutritional treatment. A group of 86 overweight/obese subjects with NAFLD from the Fatty Liver in Obesity (FLiO) study were enrolled and metabolically evaluated at baseline and after 6 months. A pre-designed panel of 95 genetic variants related to obesity and weight loss was applied and analyzed. Three genetic risk scores (GRS) concerning the improvement on hepatic health evaluated by minimally invasive methods such as the fatty liver index (FLI) (GRS

Indexed as

fatty liver indexgenetic risk scorelipidomicmagnetic resonance imagingNAFLD

Identifiers

PMID34199237
PMCPMC8231822
OpenAlexW3136712408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.