Evidence map›Paper›PMID 34199182›Full record

ReviewInternational journal of molecular sciences2021

Diet-Regulating Microbiota and Host Immune System in Liver Disease.

Jung A Eom, Goo Hyun Kwon, Na Yeon Kim, Eun Ju Park, Sung Min Won, Jin Ju Jeong, Ganesan Raja, Haripriya Gupta, Yoseph Asmelash Gebru, Satyapriya Sharma and 10 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Towards a reference cell atlas of liver diversity over the human lifespan.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. The Impact of ProbioticLife (Basel, Switzerland) · 2024
    Review
  8. Vitamin DEuropean journal of nutrition · 2024
    Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Jung A EomInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Goo Hyun KwonInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Na Yeon KimInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Eun Ju ParkInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Sung Min WonInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Jin Ju JeongInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Ganesan RajaInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0003-3060-6217
Haripriya GuptaInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0002-6008-1143
Yoseph Asmelash GebruInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Satyapriya SharmaInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Ye Rin ChoiInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0002-9731-4510
Hyeong Seop KimInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Sang Jun YoonInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0003-4712-6359
Ji Ye HyunInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Min Kyo JeongInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Hee Jin ParkInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Byeong Hyun MinInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Mi Ran ChoiInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.
Dong Joon KimInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0002-5792-1500
Ki Tae SukInstitute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea.ORCID 0000-0002-9206-9245
Hallym University · KR

Funding

Hallym University Research Fund Hallym University Research FundNational Research Foundation of Korea funded by the Ministry of Education, Science and Technology NRF-2018M3A9F3020956, NRF-2019R1I1A3A01060447, NRF-2020R1I1A3073530 and NRF-2020R1A6A1A03043026
6 · The paper itself

Abstract

The gut microbiota has been known to modulate the immune responses in chronic liver diseases. Recent evidence suggests that effects of dietary foods on health care and human diseases are related to both the immune reaction and the microbiome. The gut-microbiome and intestinal immune system play a central role in the control of bacterial translocation-induced liver disease. Dysbiosis, small intestinal bacterial overgrowth, translocation, endotoxemia, and the direct effects of metabolites are the main events in the gut-liver axis, and immune responses act on every pathways of chronic liver disease. Microbiome-derived metabolites or bacteria themselves regulate immune cell functions such as recognition or activation of receptors, the control of gene expression by epigenetic change, activation of immune cells, and the integration of cellular metabolism. Here, we reviewed recent reports about the immunologic role of gut microbiotas in liver disease, highlighting the role of diet in chronic liver disease.

Indexed as

DietAnimalsGastrointestinal MicrobiomeHumansImmune SystemLiver Diseasesgut-liver axisgut-microbiotaimmune responseliver disease

Identifiers

PMID34199182
PMCPMC8231888
OpenAlexW3171136206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.