Evidence map›Paper›PMID 34199148›Full record

ArticleCells2021

Gene Expression Profile in Different Age Groups and Its Association with Cognitive Function in Healthy Malay Adults in Malaysia.

Nur Fathiah Abdul Sani, Ahmad Imran Zaydi Amir Hamzah, Zulzikry Hafiz Abu Bakar, Yasmin Anum Mohd Yusof, Suzana Makpol, Wan Zurinah Wan Ngah, Hanafi Ahmad Damanhuri

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolomics Profiling of Age-Associated Metabolites in Malay Population.Oxidative medicine and cellular longevity · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nur Fathiah Abdul SaniDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-2638-3076
Ahmad Imran Zaydi Amir HamzahDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
Zulzikry Hafiz Abu BakarDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-8060-4220
Yasmin Anum Mohd YusofFaculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Sungai Besi, Kuala Lumpur 57000, Malaysia.
Suzana MakpolDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-5239-6196
Wan Zurinah Wan NgahDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.
Hanafi Ahmad DamanhuriDepartment of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-6948-8839
University Kebangsaan Malaysia Medical Centre · MYNational Defence University of Malaysia · MY

Funding

Ministry of Higher Education Malaysia LRGS/BU/2012/UKM-UKM/K/04
6 · The paper itself

Abstract

The mechanism of cognitive aging at the molecular level is complex and not well understood. Growing evidence suggests that cognitive differences might also be caused by ethnicity. Thus, this study aims to determine the gene expression changes associated with age-related cognitive decline among Malay adults in Malaysia. A cross-sectional study was conducted on 160 healthy Malay subjects, aged between 28 and 79, and recruited around Selangor and Klang Valley, Malaysia. Gene expression analysis was performed using a HumanHT-12v4.0 Expression BeadChip microarray kit. The top 20 differentially expressed genes at

Indexed as

AdultAgedAgingCluster AnalysisCognitionGene Expression ProfilingGene Expression RegulationHumansMalaysiaMiddle AgedPrincipal Component AnalysisReproducibility of ResultsTranscriptomeagingcognitive declinegene expressionMalay adults

Identifiers

PMID34199148
PMCPMC8304476
OpenAlexW3173361209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.