Evidence map›Paper›PMID 34199136›Full record

ArticleInternational journal of molecular sciences2021

Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth.

Laura Barberio, Luana Paulesu, Laura Canesi, Elena Grasselli, Maurizio Mandalà

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Laura BarberioDepartment of Biology, Ecology & Earth Sciences, University of Calabria, 87036 Rende, Italy.
Luana PaulesuDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-7296-308X
Laura CanesiDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy.ORCID 0000-0003-2061-3819
Elena GrasselliDepartment of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy.ORCID 0000-0003-4439-4059
Maurizio MandalàDepartment of Biology, Ecology & Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-3736-0205
University of Genoa · ITUniversity of Calabria · ITUniversity of Siena · ITUniversity of Vermont · US

Funding

MUR 2015SHM58M_004
6 · The paper itself

Abstract

Bisphenol A (BPA) is a widespread environmental contaminant, found in human fluids and tissues. Maternal BPA exposure is associated with alterations in pregnancy outcomes. Because maternal uterine circulation plays a crucial role in normal placenta and fetal growth, we hypothesized that BPA compromises the function of uterine arteries (UAs) and fetoplacental development. Female rats were orally administered with BPA (2.5, 25 and 250 µg/kg/day) or with its vehicle (ethanol) for 30 days before pregnancy and during the first 20 days of pregnancy. To compare the effect of BPA in the reproductive vs. systemic circulation, it was tested on UAs and mesenteric arteries (MAs). Arteries were isolated and examined by pressure myography. Moreover, fetuses and placentas were weighed to provide an index of reproductive performance. In UAs of BPA-treated rats, lumen diameter, acetylcholine-relaxation and expressions of endothelial nitric oxide synthase 3 (

Indexed as

Air Pollutants, OccupationalAnimalsBenzhydryl CompoundsBiomarkersBisphenol A CompoundsDose-Response Relationship, DrugFemaleFetal DevelopmentMaternal ExposurePhenolsPlacentaPregnancyRatsUterine ArteryAir Pollutants, OccupationalBenzhydryl CompoundsBiomarkersbisphenol ABisphenol A CompoundsPhenolsendothelial dysfunctionestrogen receptormaternal BPA contaminationnitric oxideperoxisome proliferator-activated receptor ɣpregnancyuterine arteries

Identifiers

PMID34199136
PMCPMC8268965
OpenAlexW3174413482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.