Evidence map›Paper›PMID 34199089›Full record

ArticleInternational journal of molecular sciences2021

Hypoxia as a Stimulus for the Maturation of Meniscal Cells: Highway to Novel Tissue Engineering Strategies?

Valentina Rafaela Herrera Millar, Laura Mangiavini, Umberto Polito, Barbara Canciani, Van Thi Nguyen, Federica Cirillo, Luigi Anastasia, Giuseppe Maria Peretti, Silvia Clotilde Modina, Alessia Di Giancamillo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Molecular Biology of Meniscal Healing: A Narrative Review.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Valentina Rafaela Herrera MillarDepartment of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.ORCID 0000-0002-6855-9279
Laura MangiaviniIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Umberto PolitoDepartment of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.ORCID 0000-0002-4503-8155
Barbara CancianiIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Van Thi NguyenIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.ORCID 0000-0003-2683-4591
Federica CirilloStem Cells for Tissue Engineering Laboratory, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-0196-5977
Luigi AnastasiaStem Cells for Tissue Engineering Laboratory, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Giuseppe Maria PerettiIRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
Silvia Clotilde ModinaDepartment of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.ORCID 0000-0002-2780-5971
Alessia Di GiancamilloDepartment of Veterinary Medicine, University of Milan, 26900 Lodi, Italy.ORCID 0000-0003-1674-3020
University of Milan · ITIstituto Ortopedico Galeazzi · ITIRCCS Policlinico San Donato · ITVita-Salute San Raffaele University · IT

Funding

Ministero della Salute L1036
6 · The paper itself

Abstract

The meniscus possesses low self-healing properties. A perfect regenerative technique for this tissue has not yet been developed. This work aims to evaluate the role of hypoxia in meniscal development in vitro. Menisci from neonatal pigs (day 0) were harvested and cultured under two different atmospheric conditions: hypoxia (1% O

Indexed as

Cell DifferentiationAnimalsBiomarkersCells, CulturedChondrocytesGene ExpressionGlycosaminoglycansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitImmunohistochemistryMeniscusSwineTissue EngineeringBiomarkersGlycosaminoglycansHypoxia-Inducible Factor 1, alpha Subunitfibro-chondrocytesglycosaminoglycansHIF-1αhypoxiameniscuspig

Identifiers

PMID34199089
PMCPMC8267734
OpenAlexW3176863192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.