Evidence map›Paper›PMID 34199001›Full record

ArticleJournal of clinical medicine2021

Intranasal Dexmedetomidine Compared to a Combination of Intranasal Dexmedetomidine with Ketamine for Sedation of Children Requiring Dental Treatment: A Randomized Clinical Trial.

Joji Sado-Filho, Patrícia Corrêa-Faria, Karolline A Viana, Fausto M Mendes, Keira P Mason, Luciane R Costa, Paulo S Costa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Article
  10. Nociception associated with pain/distress in young children sedated for dental treatment: a clinical study with objective and subjective measures.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Joji Sado-FilhoHealth Sciences Graduate Program, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia 74605-050, Brazil.
Patrícia Corrêa-FariaDentistry Graduate Program, Faculdade de Odontologia, Universidade Federal de Goiás, Goiânia 74605-220, Brazil.ORCID 0000-0002-0528-1425
Karolline A VianaDentistry Graduate Program, Faculdade de Odontologia, Universidade Federal de Goiás, Goiânia 74605-220, Brazil.ORCID 0000-0002-4647-2682
Fausto M MendesDentistry Graduate Program, Faculdade de Odontologia, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1711-4103
Keira P MasonDepartment of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-9375-7816
Luciane R CostaHealth Sciences Graduate Program, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0001-7637-0049
Paulo S CostaHealth Sciences Graduate Program, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0001-9370-9139
Universidade Federal de Goiás · BRBoston Children's Hospital · USUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Goiás 201710267000525
6 · The paper itself

Abstract

Outpatient pediatric sedation is challenging. This study aimed to test intranasal dexmedetomidine efficacy as a single drug or combined with ketamine (DK) to sedate children undergoing dental treatment. Children < 7 years were randomized into dexmedetomidine 2 mcg/kg and ketamine 1 mg/kg (DK) or dexmedetomidine 2.5 mcg/kg (D) groups. Videos from the dental sedation allowed the systematic assessment of children's behavior (primary outcome) according to the Ohio State University Behavioral Rating Scale (OSUBRS). Secondary outcomes were parental and dentist satisfaction, adverse events, and recovery time. The data were analyzed descriptively and through regression models. Participants were 88 children (44 per group; 50 boys). The duration of quiet behavior (OSUBRS) was higher than 50% (DK mean 58.4 [standard deviation 38.1]; D 55.2 [39.1];

Indexed as

dental anxietydental care for childrendexmedetomidineintranasal administrationketaminemoderate sedation

Identifiers

PMID34199001
PMCPMC8269392
OpenAlexW3174330161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.