Evidence map›Paper›PMID 34199000›Full record

ArticlePathogens (Basel, Switzerland)2021

Effectiveness and Safety of a Single-Dose Ivermectin Treatment for Uncomplicated Strongyloidiasis in Immunosuppressed Patients (ImmunoStrong Study): The Study Protocol.

Fernando Salvador, Ana Lucas-Dato, Silvia Roure, Marta Arsuaga, Asunción Pérez-Jacoiste, Magdalena García-Rodríguez, José A Pérez-Molina, Dora Buonfrate, José María Saugar, Israel Molina

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Fernando SalvadorInfectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08035 Barcelona, Spain.ORCID 0000-0002-0546-1354
Ana Lucas-DatoInternal Medicine Department, Hospital Vega Baja, 03314 Orihuela, Spain.
Silvia RoureInfectious Diseases Department, North Metropolitan International Health Unit, Germans Trias i Pujol University Hospital, PROSICS North Metropolitan, 08916 Badalona, Spain.ORCID 0000-0002-7982-0890
Marta ArsuagaTropical Medicine Unit, Infectious Diseases Department, La Paz-Carlos III University Hospital, 28046 Madrid, Spain.ORCID 0000-0001-5522-3728
Asunción Pérez-JacoisteInternal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Magdalena García-RodríguezInfectious Diseases Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain.
José A Pérez-MolinaNational Referral Unit for Tropical Diseases, Infectious Diseases Department, Hospital Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.ORCID 0000-0001-8735-4124
Dora BuonfrateDepartment of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, 37024 Verona, Italy.ORCID 0000-0003-0108-6822
José María SaugarParasitology Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Madrid, Spain.ORCID 0000-0001-8950-5766
Israel MolinaInfectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08035 Barcelona, Spain.
Vall d'Hebron Hospital Universitari · ESHospital General Universitario De Valencia · ESHospital Universitari Germans Trias i Pujol · ESHospital Universitario 12 De Octubre · ESHospital Universitario La Paz · ESHospital Vega Baja · ESInstituto de Salud Carlos III · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESOspedale Sacro Cuore Don Calabria · IT

Funding

Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica 2020 Research Grant
6 · The paper itself

Abstract

Strongyloidiasis affects an estimated 600 million people worldwide, especially in tropical and subtropical areas. Single-dose ivermectin treatment has shown to be effective among immunocompetent patients with uncomplicated strongyloidiasis. Here, we present the protocol of the ImmunoStrong study, a prospective observational study aiming to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients. The secondary objectives are to assess accuracy of molecular techniques for the follow-up of these patients and to determine the population pharmacokinetics of ivermectin. The information retrieved by this study will cover relevant information gaps in the strongyloidiasis management among immunosuppressed patients.

Indexed as

immunosuppressionivermectinPCRpopulation pharmacokineticsStrongyloides stercoralis

Identifiers

PMID34199000
PMCPMC8308528
OpenAlexW3173313031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.