Evidence map›Paper›PMID 34198994›Full record

ArticleVaccines2021

Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein.

C Joaquín Cáceres, Stivalis Cardenas-Garcia, Aarti Jain, L Claire Gay, Silvia Carnaccini, Brittany Seibert, Lucas M Ferreri, Ginger Geiger, Algimantas Jasinskas, Rie Nakajima and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

C Joaquín CáceresDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-8508-6592
Stivalis Cardenas-GarciaDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-7613-8642
Aarti JainDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
L Claire GayDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-4360-0519
Silvia CarnacciniTifton Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Tifton, GA 31793, USA.
Brittany SeibertDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Lucas M FerreriDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Ginger GeigerDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-4927-8084
Algimantas JasinskasDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Rie NakajimaDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Daniela S RajaoDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-0772-0065
Irina Isakova-SivakDepartment of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376 St Petersburg, Russia.
Larisa RudenkoDepartment of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376 St Petersburg, Russia.
Amy L VincentNational Animal Disease Center, USDA-ARS, 1920 Dayton Avenue, Ames, IA 50010, USA.
D Huw DaviesDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Daniel R PerezDepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Funding

Flu-IGIP: Live attenuated influenza virus vaccines with improved stimulation of IgA responsesR21AI146448 · NIAID · UNIVERSITY OF GEORGIA · PI PEREZ, DANIEL R · 2019 to 2020
$433k
National Institute of Allergy and Infectious Diseases 1R21AI146448-01NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated the gene encoding the IgA-inducing protein (IGIP) into the LAIV genomes of the cold-adapted A/Leningrad/134/17/57 (H2N2) strain (caLen) and the experimental attenuated backbone A/turkey/Ohio/313053/04 (H3N2) (OH/04

Indexed as

HAIgAIgGIGIPinfluenzaLAIVnatural adjuvantvaccine

Identifiers

PMID34198994
PMCPMC8310050

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.