Evidence map›Paper›PMID 34198987›Full record

ReviewCells2021

RelB and Neuroinflammation.

Karli Mockenhaupt, Alexandra Gonsiewski, Tomasz Kordula

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. NF-Frontiers in cardiovascular medicine · 2026
    Review
  7. Journal of oral microbiology · 2026
    Article
  8. Article
  9. p65 enhanced METTL3-mediated mCentral-European journal of immunology · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Ginsenosides fromInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Karli MockenhauptDepartment of Biochemistry and Molecular Biology, School of Medicine and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VI 23298, USA.
Alexandra GonsiewskiDepartment of Biochemistry and Molecular Biology, School of Medicine and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VI 23298, USA.
Tomasz KordulaDepartment of Biochemistry and Molecular Biology, School of Medicine and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VI 23298, USA.
Virginia Commonwealth University · US

Funding

Regulation of astrocyte diversity in the cerebellumR01NS122986 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI KORDULA, TOMASZ K · 2021 to 2025
$2.3M
Establishment of immunocompetent spontaneous glioma model to study glioma-associated astrocytesR21NS118359 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI KORDULA, TOMASZ K · 2021 to 2021
$427k
Ying Yang 1, a master regulator of chronic inflammation in glioblastoma multiformeR21NS102802 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI KORDULA, TOMASZ K · 2018 to 2019
$427k
NINDS NIH HHS R01 NS122986NINDS NIH HHS R21 NS102802NINDS NIH HHS R21 NS118359
6 · The paper itself

Abstract

Neuroinflammation within the central nervous system involves multiple cell types that coordinate their responses by secreting and responding to a plethora of inflammatory mediators. These factors activate multiple signaling cascades to orchestrate initial inflammatory response and subsequent resolution. Activation of NF-κB pathways in several cell types is critical during neuroinflammation. In contrast to the well-studied role of p65 NF-κB during neuroinflammation, the mechanisms of RelB activation in specific cell types and its roles during neuroinflammatory response are less understood. In this review, we summarize the mechanisms of RelB activation in specific cell types of the CNS and the specialized effects this transcription factor exerts during neuroinflammation.

Indexed as

AnimalsBrainHumansImmunosuppression TherapyInflammationNF-kappa BSignal TransductionTranscription Factor RelBNF-kappa BTranscription Factor RelBastrocytesglioblastoma multiformemicroglianeuroinflammationNF-κBoligodendrocytesRelB

Identifiers

PMID34198987
PMCPMC8307460
OpenAlexW3175154550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.