Evidence map›Paper›PMID 34198981›Full record

ArticleInternational journal of molecular sciences2021

Protective Effect of Membrane-Free Stem Cells against Lipopolysaccharide and Interferon-Gamma-Stimulated Inflammatory Responses in RAW 264.7 Macrophages.

Mei Tong He, Hye Sook Park, Young Sil Kim, Ah Young Lee, Eun Ju Cho

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Anti-Inflammatory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mei Tong HeDepartment of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.
Hye Sook ParkDepartment of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.
Young Sil KimT-Stem Co., Ltd., Changwon 51573, Korea.
Ah Young LeeDepartment of Food Science, Gyeongsang National University, Jinju 52725, Korea.
Eun Ju ChoDepartment of Food Science and Nutrition, Pusan National University, Busan 46241, Korea.ORCID 0000-0003-4282-3219
Pusan National University · KRGyeongsang National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, adipose-derived stem cells (ADSCs) are considered to be ideal for application in cell therapy or tissue regeneration, mainly due to their wide availability and easy access. In this study, we examined the anti-inflammatory effects of membrane-free stem cell extract (MFSC-Ex) derived from ADSCs against lipopolysaccharide (LPS)/interferon-gamma (IFN-γ) on RAW 264.7 macrophage cells. Exposure of RAW macrophages to LPS and IFN-γ stimuli induced high levels of nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E

Indexed as

Adipose TissueAnimalsAnti-Inflammatory AgentsCell SurvivalCyclooxygenase 2DinoprostoneInterferon-gammaLipopolysaccharidesMacrophagesMiceModels, BiologicalProtective AgentsRAW 264.7 CellsStem CellsAnti-Inflammatory AgentsCyclooxygenase 2DinoprostoneInterferon-gammaLipopolysaccharidesProtective Agentsanti-inflammatory effectinterferon-gammalipopolyssacharidemembrane-free stem cellRAW 264.7 macrophage

Identifiers

PMID34198981
PMCPMC8268248
OpenAlexW3174920406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.