Evidence map›Paper›PMID 34198846›Full record

ArticleBiomedicines2021

Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer.

Luis Javier Martínez-González, Victor Sánchez-Conde, Jose María González-Cabezuelo, Alba Antunez-Rodríguez, Eduardo Andrés-León, Inmaculada Robles-Fernandez, Jose Antonio Lorente, Fernando Vázquez-Alonso, María Jesus Alvarez-Cubero

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. The role of exosomes in bladder cancer immunotherapy.Journal of the National Cancer Center · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. mCancers · 2022
    Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Luis Javier Martínez-GonzálezGENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Genomics Unit, PTS Granada-Avenida de la Ilustración, 114-18016 Granada, Spain.ORCID 0000-0003-2202-0662
Victor Sánchez-CondeUrology Department, Hospital Virgen de las Nieves, 18014 Granada, Spain
Jose María González-CabezueloResearch and Development Department, Meridiem Seeds, 04710 Almería, Spain
Alba Antunez-RodríguezGENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Genomics Unit, PTS Granada-Avenida de la Ilustración, 114-18016 Granada, Spain.ORCID 0000-0002-3963-6546
Eduardo Andrés-LeónBioinformatics Unit, Institute of Parasitology and Biomedicine “López-Neyra” (IPBLN), Spanish National Research Council (CSIC), 18016 Granada, SpainORCID 0000-0002-0621-9914
Inmaculada Robles-FernandezGENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Liquid Biopsy and Cancer Interception Group, PTS Granada, 114-18016 Granada, Spain.
Jose Antonio LorenteGENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Liquid Biopsy and Cancer Interception Group, PTS Granada, 114-18016 Granada, Spain.ORCID 0000-0002-9892-7386
Fernando Vázquez-AlonsoUrology Department, Hospital Virgen de las Nieves, 18014 Granada, SpainORCID 0000-0003-3819-3832
María Jesus Alvarez-CuberoGENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Liquid Biopsy and Cancer Interception Group, PTS Granada, 114-18016 Granada, Spain.ORCID 0000-0002-5492-9355
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESHospital Universitario Virgen de las Nieves · ESUniversidad de Granada · ESConsejo Superior de Investigaciones Científicas · ES

Funding

Consejería de Salud y Familias, Junta de Andalucía PI-0319-2018
6 · The paper itself

Abstract

MiRNAs play a relevant role in PC (prostate cancer) by the regulation in the expression of several pathways' AR (androgen receptor), cellular cycle, apoptosis, MET (mesenchymal epithelium transition), or metastasis. Here, we report the role of several miRNAs' expression patterns, such as miR-93-5p, miR-23c, miR-210-3p, miR-221-3p, miR-592, miR-141, miR-375, and miR-130b, with relevance in processes like cell proliferation and MET. Using Trizol

Indexed as

aggressivenessbioinformaticbiomarkersprecision medicineprostate cancer

Identifiers

PMID34198846
PMCPMC8227559
OpenAlexW3169986309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.