ArticleInternational journal of molecular sciences2021
Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy.
Andi K Cani, Marcus A Toral, Daniel A Balikov, Bryan L Betz, Kevin Hu, Chia-Jen Liu, Matthew V Prifti, Arul M Chinnaiyan, Scott A Tomlins, Vinit B Mahajan and 1 more
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 4 institutions in 1 country.
Andi K CaniDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Marcus A ToralMedical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA.
Daniel A BalikovW.K. Kellogg Eye Center, Department of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0003-0392-5087
Bryan L BetzDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Kevin HuDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Chia-Jen LiuDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew V PriftiA. Alfred Taubman Medical Research Institute, University of Michigan, Ann Arbor, MI 48105, USA.
Arul M ChinnaiyanRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Scott A TomlinsDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Vinit B MahajanMolecular Surgery Laboratory, Byers Eye Institute, Stanford University, Palo Alto, CA 94303, USA.
Rajesh C RaoRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5776-8366
University of Michigan · USUniversity of Iowa · USVA Palo Alto Health Care System · USWayne State University · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
Improving rigor and reproducibility in adaptive optics ophthalmoscopyR01EY031360 · NEI · STANFORD UNIVERSITY · PI DUBRA, ALFREDO · 2020 to 2023
$2.3M
Molecular Determinants for WDR5-Driven Transcriptional Regulation at Lineage-Specifying Genes During RetinogenesisR01EY030989 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, RAJESH C. · 2020 to 2024
$2.2M
Inflammatory Gene Transcription in the RetinaR01EY030151 · NEI · STANFORD UNIVERSITY · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2020 to 2024
$2.0M
Proteomic Biomarkers of Intraocular InfectionR01EY031952 · NEI · STANFORD UNIVERSITY · PI BASSUK, ALEXANDER G, FERGUSON, POLLY J · 2020 to 2023
$1.6M
Training Program in Translational ResearchT32GM113900 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P, NIKOLOVSKA-COLESKA, ZANETA · 2016 to 2020
$991k
Epigenetic Control of Retinal DevelopmentK08EY026654 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, RAJESH C. · 2017 to 2019
Vitreoretinal lymphoma (VRL) is an uncommon eye malignancy, and VRLs of T cell origin are rare. They are difficult to treat, and their molecular underpinnings, including actionable genomic alterations, remain to be elucidated. At present, vitreous fluid liquid biopsies represent a valuable VRL sample for molecular analysis to study VRLs. In this study, we report the molecular diagnostic workup of a rare case of bilateral T cell VRL and characterize its genomic landscape, including identification of potentially targetable alterations. Using next-generation sequencing of vitreous-derived DNA with a pan-cancer 126-gene panel, we found a copy number gain of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy. · full record | OpenQuestion