Evidence map›Paper›PMID 34198819›Full record

ArticleBiomolecules2021

Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis.

Balagra Kasim Sumabe, Synnøve Brandt Ræder, Lisa Marie Røst, Animesh Sharma, Eric S Donkor, Lydia Mosi, Samuel Duodu, Per Bruheim, Marit Otterlei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Activation of multiple stress responses inFrontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Balagra Kasim SumabeDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.ORCID 0000-0003-1639-1854
Synnøve Brandt RæderDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.ORCID 0000-0002-1562-6343
Lisa Marie RøstDepartment of Biotechnology and Food Science, Faculty of Natural Sciences, NTNU Norwegian University of Science and Technology, NO-7481 Trondheim, Norway.ORCID 0000-0003-3980-8667
Animesh SharmaProteomics and Modomics Experimental Core Facility (PROMEC), NTNU Norwegian University of Science and Technology, NO-7481 Trondheim, Norway.
Eric S DonkorDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box 4236 Accra, Ghana.
Lydia MosiWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. BOX LG 54 Accra, Ghana.
Samuel DuoduWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. BOX LG 54 Accra, Ghana.
Per BruheimDepartment of Biotechnology and Food Science, Faculty of Natural Sciences, NTNU Norwegian University of Science and Technology, NO-7481 Trondheim, Norway.ORCID 0000-0002-7851-8083
Marit OtterleiDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.ORCID 0000-0002-5232-1186
Norwegian University of Science and Technology · NOUniversity of Ghana · GH

Funding

Welcome Trust 107755/Z/15/Z
6 · The paper itself

Abstract

Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here, we have examined nucleoside analogues (NAs) commonly used in anti-viral and anti-cancer therapies for potential effects on mutagenesis in

Indexed as

Antineoplastic AgentsAntiviral AgentsDNA-Directed DNA PolymeraseEscherichia coli ProteinsMicrobial Sensitivity TestsMutagenesisNucleosidesStavudineAntineoplastic AgentsAntiviral AgentsDNA-Directed DNA PolymeraseDNA polymerase V, E coliEscherichia coli ProteinsNucleosidesStavudineAMRMDRNANRTIsPol VSOSTLSβ-clamp

Identifiers

PMID34198819
PMCPMC8227612
OpenAlexW3172016739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.