Evidence map›Paper›PMID 34198818›Full record

ReviewJournal of clinical medicine2021

How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR.

Clara García-Carro, Ander Vergara, Sheila Bermejo, María A Azancot, Ana I Sánchez-Fructuoso, M Dolores Sánchez de la Nieta, Irene Agraz, María José Soler

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05631119 (Biorepository of Biospecimen Samples in Matched Healthy Control Participants and Participants Diagnosed With Diabetic Kidney Disease, Chronic Kidney Disease, or Type 2 Diabetes), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05631119 completednot on this mapstarted 2022, after this paper: background citation

Biorepository of Biospecimen Samples in Matched Healthy Control Participants and Participants Diagnosed With Diabetic Kidney Disease, Chronic Kidney Disease, or Type 2 Diabetes

Typeobservational_patient_registrySponsorSanguine BiosciencesRan2022 to 2023Enrolled40ConditionsDiabetic Kidney Disease, Diabetes Type 2, Chronic Kidney Diseases, Healthy
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Epidemiology of Diabetic Kidney Disease among US Veterans.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Cardiorenal syndrome and diabetes: an evil pairing.Frontiers in cardiovascular medicine · 2023
    Review
  11. Review
  12. Cardiometabolic Risk Factors Associated With Type 2 Diabetes Mellitus: A Mechanistic Insight.Clinical medicine insights. Endocrinology and diabetes · 2023
    Review
  13. Article
  14. Recent advances in nephropathy biomarker detections using paper-based analytical devices.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clara García-CarroNephrology Department, San Carlos Clinical University Hospital, 28040 Madrid, Spain.
Ander VergaraNephrology Research Group, Nephrology Department, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebrón Hospital Universitari, 08035 Barcelona, Spain.
Sheila BermejoNephrology Research Group, Nephrology Department, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebrón Hospital Universitari, 08035 Barcelona, Spain.ORCID 0000-0002-3611-4830
María A AzancotNephrology Research Group, Nephrology Department, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebrón Hospital Universitari, 08035 Barcelona, Spain.
Ana I Sánchez-FructuosoNephrology Department, San Carlos Clinical University Hospital, 28040 Madrid, Spain.
M Dolores Sánchez de la NietaNephrology Department, San Carlos Clinical University Hospital, 28040 Madrid, Spain.
Irene AgrazNephrology Research Group, Nephrology Department, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebrón Hospital Universitari, 08035 Barcelona, Spain.ORCID 0000-0002-4223-6834
María José SolerNephrology Research Group, Nephrology Department, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebrón Hospital Universitari, 08035 Barcelona, Spain.
Vall d'Hebron Institut de Recerca · ESHospital Clínico San Carlos · ES

Funding

Fondo de Investigación Sanitaria-Feder-Instituto de Salud Carlos III PI17/00257REDinREN RD16/0009/0030
6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way.

Indexed as

chronic kidney diseasediabetes mellitusdiabetic kidney disease

Identifiers

PMID34198818
PMCPMC8201333
OpenAlexW3167580704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.