Evidence map›Paper›PMID 34198757›Full record

ArticleGenes2021

Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Atsushi WatanabeDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.ORCID 0000-0002-4181-8111
Kunio MiyakeDepartment of Health Sciences, University of Yamanashi, Yamanashi 409-3898, Japan.
Koshi AkahaneDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Kumiko GoiDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Keiko KagamiDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Hideo YagitaDepartment of Immunology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Takeshi InukaiDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
University of Yamanashi · JPJuntendo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapies specific for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), such as anti-CD19 chimeric antigen receptor (CAR) T-cells and blinatumomab, have dramatically improved the therapeutic outcome in refractory cases. In the anti-leukemic activity of those immunotherapies, TNF-related apoptosis-inducing ligand (TRAIL) on cytotoxic T-cells plays an essential role by inducing apoptosis of the target leukemia cells through its death receptors (DR4 and DR5). Since there are CpG islands in the promoter regions, hypermethylation of the

Indexed as

DNA MethylationDrug Resistance, NeoplasmEpigenesis, GeneticCell Line, TumorCpG IslandsHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticReceptors, TNF-Related Apoptosis-Inducing LigandTNF-Related Apoptosis-Inducing LigandReceptors, TNF-Related Apoptosis-Inducing LigandTNF-Related Apoptosis-Inducing LigandTNFRSF10B protein, humanB-cell precursor acute lymphoblastic leukemiadeath receptorsepigeneticsTNF-related apoptosis-inducing ligand

Identifiers

PMID34198757
PMCPMC8229974
OpenAlexW3165988373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.