Evidence map›Paper›PMID 34198741›Full record

ReviewAntibiotics (Basel, Switzerland)2021

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis.

Saartje Uyttebroek, Jolien Onsea, Willem-Jan Metsemakers, Lieven Dupont, David Devolder, Jeroen Wagemans, Rob Lavigne, Isabel Spriet, Laura Van Gerven

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Antibiotic Resistance ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Saartje UyttebroekDepartment of Otorhinolaryngology, UZ Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-3834-6029
Jolien OnseaDepartment of Trauma Surgery, UZ Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-5096-5789
Willem-Jan MetsemakersDepartment of Trauma Surgery, UZ Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4114-9093
Lieven DupontDepartment of Pneumology, UZ Leuven, 3000 Leuven, Belgium.
David DevolderPharmacy Department, UZ Leuven, 3000 Leuven, Belgium.
Jeroen WagemansDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2185-5724
Rob LavigneDepartment of Biosystems, Laboratory of Gene Technology, KU Leuven, 3000 Leuven, Belgium.
Isabel SprietPharmacy Department, UZ Leuven, 3000 Leuven, Belgium.
Laura Van GervenDepartment of Otorhinolaryngology, UZ Leuven, 3000 Leuven, Belgium.
Universitair Ziekenhuis Leuven · BEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic rhinosinusitis is a common condition affecting 5-12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by

Indexed as

bacteriophageschronic rhinosinusitisendolysinsphagesphage therapyrecalcitrantrefractorytherapy-resistant

Identifiers

PMID34198741
PMCPMC8229554
OpenAlexW3170655322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.