Evidence map›Paper›PMID 34198715›Full record

ArticleInternational journal of environmental research and public health2021

SARS-CoV-2 Infection in Health Workers: Analysis from Verona SIEROEPID Study during the Pre-Vaccination Era.

Stefano Porru, Maria Grazia Lourdes Monaco, Angela Carta, Gianluca Spiteri, Marco Parpaiola, Andrea Battaggia, Giulia Galligioni, Beatrice Ferrazzi, Giuliana Lo Cascio, Davide Gibellini and 9 more

Open access · goldAbstract read
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In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Stefano PorruSection of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Maria Grazia Lourdes MonacoClinical Unit of Occupational Medicine, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0003-4951-2528
Angela CartaSection of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-3620-8765
Gianluca SpiteriClinical Unit of Occupational Medicine, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0001-8536-7095
Marco ParpaiolaPostgraduate School of Occupational Medicine, University of Verona, 37134 Verona, Italy.
Andrea BattaggiaPostgraduate School of Occupational Medicine, University of Verona, 37134 Verona, Italy.
Giulia GalligioniPostgraduate School of Occupational Medicine, University of Verona, 37134 Verona, Italy.
Beatrice FerrazziPostgraduate School of Occupational Medicine, University of Verona, 37134 Verona, Italy.
Giuliana Lo CascioLocal Heath Authority of Piacenza, 29121 Piacenza, Italy.
Davide GibelliniSection of Microbiology, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.
Angelo PerettiUnit of Microbiology and Virology, University Hospital of Verona, 37134 Verona, Italy.
Martina BruttiUnit of Microbiology and Virology, University Hospital of Verona, 37134 Verona, Italy.
Stefano TardivoSection of Hygiene, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-9161-2189
Giovanna GhirlandaMedical Direction, University Hospital of Verona, 37134 Verona, Italy.
Giuseppe VerlatoUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-5262-8818
Stefania GainoLaboratory of Clinical Chemistry and Hematology, University Hospital of Verona, 37134 Verona, Italy.
Denise PesericoSection of Clinical Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Antonella BassiLaboratory of Clinical Chemistry and Hematology, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0002-5370-9828
Giuseppe LippiLaboratory of Clinical Chemistry and Hematology, University Hospital of Verona, 37134 Verona, Italy.ORCID 0000-0001-9523-9054
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo report the baseline phase of the SIEROEPID study on SARS-CoV-2 infection seroprevalence among health workers at the University Hospital of Verona, Italy, between spring and fall 2020; to compare performances of several laboratory tests for SARS-CoV-2 antibody detection.

methods5299 voluntary health workers were enrolled from 28 April 2020 to 28 July 2020 to assess immunological response to SARS-CoV-2 infection throughout IgM, IgG and IgA serum levels titration by four laboratory tests. Association of antibody titre with several demographic variables, swab tests and performance tests (sensitivity, specificity, and agreement) were statistically analyzed.

resultsThe overall seroprevalence was 6%, considering either IgG and IgM, and 4.8% considering IgG. Working in COVID-19 Units was not associated with a statistically significant increase in the number of infected workers. Cohen's kappa of agreement between MaglumiTM and VivaDiagTM was quite good when considering IgG only (Cohen's kappa = 78.1%, 95% CI 74.0-82.0%), but was lower considering IgM (Cohen's kappa = 13.3%, 95% CI 7.8-18.7%).

conclusionThe large sample size with high participation (84.7%), the biobank and the longitudinal design were significant achievements, offering a baseline dataset as the benchmark for risk assessment, health surveillance and management of SARS-CoV-2 infection for the hospital workforce, especially considering the ongoing vaccination campaign. Study results support the national regulator guidelines on using swabs for SARS-CoV-2 screening with health workers and using the serological tests to contribute to the epidemiological assessment of the spread of the virus.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralHumansImmunoglobulin MItalySeroepidemiologic StudiesVaccinationAntibodies, ViralImmunoglobulin Mhealth workersSARS-CoV-2 infectionserosurvey

Identifiers

PMID34198715
PMCPMC8296263
OpenAlexW3171046206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.