Evidence map›Paper›PMID 34198654›Full record

ReviewInternational journal of molecular sciences2021

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology.

Ljuba C Ponomarev, Jakub Ksiazkiewicz, Michael W Staring, Aernout Luttun, An Zwijsen

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ljuba C PonomarevDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium.ORCID 0000-0003-0721-168X
Jakub KsiazkiewiczDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium.ORCID 0000-0003-1060-2710
Michael W StaringDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium.
Aernout LuttunDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium.
An ZwijsenDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium.ORCID 0000-0002-8583-1721
KU Leuven · BE

Funding

Fonds Wetenschappelijk Onderzoek G0B4819NFonds Wetenschappelijk Onderzoek W001420NKoning Boudewijnstichting 2020-J1190990-215254KU Leuven C14/19/095
6 · The paper itself

Abstract

Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular context, which includes flow hemodynamics, interplay with other vascular signaling cascades and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix. In this review, the emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.

Indexed as

Signal TransductionAnimalsBlood VesselsBone Morphogenetic ProteinsHumansLymphatic VesselsBone Morphogenetic ProteinsBMPBMP pathway fine-tuninglymphatic vessel biologymechano-transductionsignaling cross-talkvascular malformations

Identifiers

PMID34198654
PMCPMC8232321
OpenAlexW3172813377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.