Evidence map›Paper›PMID 34198622›Full record

ArticleBiology2021

SARS-CoV-2 Variants in Lebanon: Evolution and Current Situation.

Nancy Fayad, Walid Abi Habib, Ahmed Kandeil, Rabeh El-Shesheny, Mina Nabil Kamel, Youmna Mourad, Jacques Mokhbat, Ghazi Kayali, Jimi Goldstein, Jad Abdallah

Open access · goldAbstract read
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Nancy FayadSchool of Pharmacy, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Walid Abi HabibSchool of Pharmacy, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Ahmed KandeilCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.ORCID 0000-0003-3253-6961
Rabeh El-SheshenyCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.ORCID 0000-0002-8798-2240
Mina Nabil KamelCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.
Youmna MouradAl Hadi Laboratory and IVF Center, P.O. Box 44, Beirut, Lebanon.
Jacques MokhbatSchool of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Ghazi KayaliHuman Link, Dubai 971, United Arab Emirates.
Jimi GoldsteinHuman Link, Dubai 971, United Arab Emirates.
Jad AbdallahSchool of Pharmacy, Lebanese American University, P.O. Box 36, Byblos, Lebanon.ORCID 0000-0001-5267-4953
Lebanese American University · LBNational Research Centre · EGSt. Jude Children's Research Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of Hertfordshire · GB

Funding

National Council for Scientific Research - Lebanon CNRS-849NIAID NIH HHS HHSN272201400006C
6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen a worldwide spread since its emergence in 2019, including to Lebanon, where 534,968 confirmed cases (8% of the population) and 7569 deaths have been reported as of 14 May 2021. With the genome sequencing of strains from various countries, several classification systems were established via genome comparison. For instance, the GISAID clades classification highlights key mutations in the encoded proteins that could potentially affect the virus' infectivity and transmission rates. In this study, 58 genomes of Lebanese SARS-CoV-2 strains were analyzed, 28 of which were sequenced for this study, and 30 retrieved from the GISAID and GenBank databases. We aimed to classify these strains, establish their phylogenetic relationships, and extract the mutations causing amino acid substitutions within, particularly, the structural proteins. The sequenced Lebanese SARS-COV-2 strains were classified into four GISAID clades and 11 Pango lineages. Moreover, 21 uncommon mutations in the structural proteins were found in the newly sequenced strains, underlining interesting combinations of mutations in the spike proteins. Hence, this study constitutes an observation and description of the current SARS-CoV-2 genetic and clade situation in Lebanon according to the available sequenced strains.

Indexed as

cladesCOVID-19GISAIDLebanonmutationsphylogenetic relationship

Identifiers

PMID34198622
PMCPMC8232177
OpenAlexW3171137864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.