Evidence map›Paper›PMID 34198577›Full record

ArticleInternational journal of molecular sciences2021

Toxicity of Jegosaponins A and B from

Moe Nishimura, Hiroyuki Fuchino, Kaoru Takayanagi, Hitomi Kawakami, Hiroko Nakayama, Nobuo Kawahara, Yasuhito Shimada

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Zebrafish live imaging: a strong weapon in anticancer drug discovery and development.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  2. Chemical Constituents and Their Biological Activities from GenusPharmaceuticals (Basel, Switzerland) · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Moe NishimuraDepartment of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Hiroyuki FuchinoResearch Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Hachimandai, Tsukuba, Ibaraki 305-0843, Japan.ORCID 0000-0002-6302-4507
Kaoru TakayanagiDepartment of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Hitomi KawakamiResearch Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Hachimandai, Tsukuba, Ibaraki 305-0843, Japan.
Hiroko NakayamaMie University Zebrafish Drug Screening Center, Tsu, Mie 514-8507, Japan.ORCID 0000-0001-7335-6428
Nobuo KawaharaResearch Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, Hachimandai, Tsukuba, Ibaraki 305-0843, Japan.ORCID 0000-0002-1301-7114
Yasuhito ShimadaDepartment of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.ORCID 0000-0002-4111-8262
Mie University · JPNational Institute of Biomedical Innovation, Health and Nutrition · JPMakino Botanical Garden · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Screening of medicinal herbs is one of the most powerful approaches to identifying novel therapeutic molecules against many human diseases. To avoid potential harmful effects during medicinal use, toxicity testing is necessary in the early stages of drug discovery. The objective of this study was to identify the cytotoxic mechanisms of jegosaponin A and B from

Indexed as

AnimalsCell DeathCell Line, TumorCell Membrane PermeabilityEmbryo, NonmammalianMaleProstatic NeoplasmsSaponinsSheepStyraxToxicity Tests, AcuteZebrafishSaponinsanti-cancerscreeningtoxicology

Identifiers

PMID34198577
PMCPMC8246325
OpenAlexW3172554327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.