Evidence map›Paper›PMID 34198503›Full record

ReviewBiomolecules2021

Welcome to the Family: Identification of the NAD

Mathias Ziegler, Magnus Monné, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, Ferdinando Palmieri

Abstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Mitochondrial NADScience advances · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The mitochondrial NADMetabolism: clinical and experimental · 2022
    Article
  14. Balancing NADCellular and molecular life sciences : CMLS · 2022
    Review
  15. Review
  16. Fueling genome maintenance: On the versatile roles of NADThe Journal of biological chemistry · 2022
    Review
  17. Synthesis of Mixed Dinucleotides by Mechanochemistry.Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mathias ZieglerDepartment of Biomedicine, University of Bergen, 5009 Bergen, Norway.ORCID 0000-0001-6961-2396
Magnus MonnéDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0003-2344-3878
Andrey NikiforovInstitute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg, Russia.
Gennaro AgrimiDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0002-5219-4412
Ines HeilandDepartment of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037 Tromsø, Norway.ORCID 0000-0002-9124-5112
Ferdinando PalmieriDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via E. Orabona 4, 70125 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes can be transported across their surrounding membranes. Indeed, in mammals, there are hundreds of genes encoding solute carriers (SLCs) which mediate the selective transport of molecules such as nucleotides, amino acids, and sugars across biological membranes. Research over many years has identified the localization and preferred substrates of a large variety of SLCs. Of particular interest has been the SLC25 family, which includes carriers embedded in the inner membrane of mitochondria to secure the supply of these organelles with major metabolic intermediates and coenzymes. The substrate specificity of many of these carriers has been established in the past. However, the route by which animal mitochondria are supplied with NAD

Indexed as

Biological TransportHumansMitochondriaMitochondrial Membrane Transport ProteinsNADSolute Carrier ProteinsMitochondrial Membrane Transport ProteinsNADSolute Carrier Proteinsmembrane transportmitochondriamitochondrial carriermitochondrial transporterNADNAD+ transportersSLC25SLC25A51solute carrier family 25

Identifiers

PMID34198503
PMCPMC8231866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.