ArticleCancer epidemiology2021
Early-onset colorectal cancer risk extends to second- and third-degree relatives.
Article in Cancer epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- The change in epidemiological characteristics and utilization of health services for the diagnosis and treatment of colorectal cancer: A hospital-based retrospective survey.Clinics (Sao Paulo, Brazil) · 2026Article
- Incidence, Risk and Trends of Multiple Primary Cancers in Patients With Colorectal Cancer: Evidence From the South Australian Cancer Registry.Cancer medicine · 2025Article
- Epidemiology of colorectal cancer: A review with special emphasis on India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Sex and age-related differences in one-, three-, and five-year survival for early-onset colorectal cancer in Georgia.American journal of cancer research · 2025Article
- Chemopreventive strategies for sporadic colorectal cancer: a narrative review.Translational gastroenterology and hepatology · 2025Review
- Factors Affecting Cancer Mortality in Young Adults: Findings from a Prospective Cohort Study.Cancers · 2024Article
- The Development and Evaluation of Novel Patient Educational Material for a Variant of Uncertain Significance (VUS) Result in Hereditary Cancer Genes.Current oncology (Toronto, Ont.) · 2024Article
- Review
- Early-Onset Colorectal Cancer Survival Differences and Potential Geographic Determinants Among Men and Women in Utah.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionFamily history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown.
methodsWe estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database.
resultsWe observed elevated risks beyond RR = 2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively. DISCUSSION: Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.