Evidence map›Paper›PMID 34198230›Full record

Trial reportBehaviour research and therapy2021

The temporal sequence of change in PTSD symptoms and hypothesized mediators in Cognitive Processing Therapy and Written Exposure Therapy for PTSD.

Daniel J Lee, Brian P Marx, Johanna Thompson-Hollands, Matthew W Gallagher, Patricia A Resick, Denise M Sloan

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. The effect of time since index trauma on trauma-related beliefs.Psychological trauma : theory, research, practice and policy · 2024
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Obsessive Beliefs in Posttraumatic Stress Disorder.Journal of rational-emotive and cognitive-behavior therapy : RET · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Daniel J LeeNational Center for PTSD, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA. Electronic address: Daniel.Lee14@va.gov.
Brian P MarxNational Center for PTSD, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA.
Johanna Thompson-HollandsNational Center for PTSD, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA.
Matthew W GallagherDepartment of Psychology, University of Houston, Houston, TX, USA.
Patricia A ResickDuke Health, Durham, NC, USA.
Denise M SloanNational Center for PTSD, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA.
VA Boston Healthcare System · USDuke University Health System · USUniversity of Houston · US

Funding

Postdoctoral Training Program in Stress and TraumaT32MH019836 · NIMH · TUFTS UNIVERSITY BOSTON · PI DENISE M. SLOAN · 1996 to 2026
$4.7M
Written Exposure Therapy for PTSD: A Randomized Noninferiority TrialR01MH095737 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SLOAN, DENISE M. · 2012 to 2016
$1.4M
An adjunctive family intervention for individual PTSD treatmentIK2CX001589 · VA · VA BOSTON HEALTH CARE SYSTEM · PI THOMPSON-HOLLANDS, JOHANNA · 2017 to 2021
–
CSRD VA IK2 CX001589NIMH NIH HHS R01 MH095737NIMH NIH HHS T32 MH019836
6 · The paper itself

Abstract

We examined whether extinction or changes negative trauma-related beliefs occur either prior to or concurrently with changes in posttraumatic stress symptoms among individuals who received either Cognitive Processing Therapy (CPT) or Written Exposure Therapy (WET) using statistical methods that permit proper discernment of temporal sequence. Community participants with PTSD (N = 126) were evenly randomized to 12 sessions of CPT or 5 sessions of WET. We assessed within- and between-session changes in arousal and valence and changes in trauma-related beliefs 6-, 12-, 24-, 36- and 60-weeks following the first treatment session. Between-session change in post-session emotional valence temporally preceded PTSD symptom reduction among participants who received WET but did not predict subsequent symptom reduction. Although negative trauma-related beliefs changed in parallel with and correlated with PTSD symptom reduction in both conditions, this change did not temporally precede symptom reduction. Our results are inconsistent with those from prior studies and suggest these constructs may more appropriately be characterized as correlates, rather than mediators, of symptom reduction. These results highlight the value of discernment of the temporal sequence of change between hypothesized mediators and symptoms and underscore that we still have much to learn about how evidence-based treatments reduce PTSD symptoms.

Indexed as

Cognitive Behavioral TherapyImplosive TherapyStress Disorders, Post-TraumaticVeteransHumansTreatment OutcomeWritingCognitive therapyExposure-based treatmentMediationPTSD

Identifiers

PMID34198230
PMCPMC8325637
OpenAlexW3176505608

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.