Evidence map›Paper›PMID 34198140›Full record

ArticleNeurobiology of aging2021

Previous estradiol treatment during midlife maintains transcriptional regulation of memory-related proteins by ERα in the hippocampus in a rat model of menopause.

Nina E Baumgartner, Katelyn L Black, Shannon M McQuillen, Jill M Daniel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nina E BaumgartnerBrain Institute, Tulane University, New Orleans, LA; Neuroscience Program, Tulane University, New Orleans, LA. Electronic address: nbaumgar@tulane.edu.
Katelyn L BlackBrain Institute, Tulane University, New Orleans, LA; Neuroscience Program, Tulane University, New Orleans, LA.
Shannon M McQuillenBrain Institute, Tulane University, New Orleans, LA; Neuroscience Program, Tulane University, New Orleans, LA.
Jill M DanielBrain Institute, Tulane University, New Orleans, LA; Neuroscience Program, Tulane University, New Orleans, LA; Psychology Department, Tulane University, New Orleans, LA.
Tulane University · US

Funding

Short-term estradiol use in middle-age: implications for female cognitive agingRF1AG041374 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DANIEL, JILL M · 2018 to 2019
$2.3M
NIA NIH HHS RF1 AG041374
6 · The paper itself

Abstract

Previous midlife estradiol treatment, like continuous treatment, improves memory and results in lasting increases in hippocampal levels of estrogen receptor (ER) α and ER-dependent transcription in ovariectomized rodents. We hypothesized that previous and continuous midlife estradiol act to specifically increase levels of nuclear ERα, resulting in transcriptional regulation of proteins that mediate estrogen effects on memory. Ovariectomized middle-aged rats received estradiol or vehicle capsule implants. After 40 days, rats initially receiving vehicle received another vehicle capsule (ovariectomized controls). Rats initially receiving estradiol received either another estradiol (continuous estradiol) or a vehicle (previous estradiol) capsule. One month later, hippocampi were dissected and processed. Continuous and previous estradiol increased levels of nuclear, but not membrane or cytosolic ERα and had no effect on Esr1. Continuous and previous estradiol impacted gene expression and/or protein levels of mediators of estrogenic action on memory including ChAT, BDNF, and PSD-95. Findings demonstrate a long-lasting role for hippocampal ERα as a transcriptional regulator of memory following termination of previous estradiol treatment in a rat model of menopause.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorDisks Large Homolog 4 ProteinEstradiolEstrogen Receptor alphaFemaleGene ExpressionHippocampusMemoryMenopauseModels, AnimalOvariectomyRatsRats, Long-EvansTranscription, GeneticBdnf protein, ratBrain-Derived Neurotrophic FactorDisks Large Homolog 4 ProteinDlg4 protein, ratEstradiolEstrogen Receptor alphaBDNFChATEstrogenEstrogen receptorHippocampusMenopause

Identifiers

PMID34198140
PMCPMC8338908
OpenAlexW3171572930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.